|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
In summary, these findings expand current views on the initiation of psoriasis and related arthritis by revealing the keratinocyte-intrinsic role of TTP.
|
28570274 |
2017 |
|
Arthritis
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Substitution of TTP phosphorylation sites conferred dramatic protection against inflammatory arthritis in mice.
|
27597652 |
2017 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
When the gene encoding TTP is disrupted in mice, the animals develop a severe syndrome of arthritis, autoimmunity, cachexia, dermatitis, and myeloid hyperplasia.
|
27503556 |
2016 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
Along with decreased proinflammatory cytokines in their paw joints, there were significant functional and histologic improvements in the inflammatory arthritis of TTP(-/-) mice when CCL3 was absent, although cachexia, reflecting systemic inflammation, was notably unaffected.
|
21784977 |
2011 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
BEFREE |
In mice, TTP deficiency results in a systemic autoimmune inflammatory syndrome with severe arthritis.
|
16546352 |
2006 |
|
Arthritis
|
0.360 |
Biomarker
|
disease |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Arthritis
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.
|
15535838 |
2004 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to elucidate the role of TTP in hepatocarcinogenesis and HCC progression.
|
31717307 |
2019 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Quantitative analysis showed that IMAX, RT, TTP, and mTT of HCC were statistically different with that of reference liver parenchyma (all p ＜ .001).
|
30300039 |
2019 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MK2 was activated in primary HCC that express TTP at high level.
|
27619201 |
2016 |
|
Cachexia
|
0.340 |
Biomarker
|
phenotype |
BEFREE |
Mice deficient of TTP (TTP(-/-)) develop a systemic autoimmune inflammatory syndrome characterized by cachexia, conjunctivitis, and dermatitis.
|
23997224 |
2013 |
|
Cachexia
|
0.340 |
Biomarker
|
phenotype |
BEFREE |
TTP(-/-) mice spontaneously develop an inflammatory syndrome characterized by cachexia, myeloid hyperplasia, dermatitis, and erosive arthritis.
|
23940256 |
2013 |
|
Cachexia
|
0.340 |
Biomarker
|
phenotype |
BEFREE |
TTP-deficient (knockout [KO]) mice exhibit an early-onset, severe inflammatory phenotype, with cachexia, erosive arthritis, left-sided cardiac valvulitis, myeloid hyperplasia, and autoimmunity, which can be prevented by injections of anti-TNF Abs, or interbreeding with TNF receptor-deficient mice.
|
22491258 |
2012 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Abrogation of the post-transcriptional regulation of c-Myc via methylation of a specific single CpG site in the TTP promoter presents a novel mechanism for the gain of selective resistance to the antiproliferative signaling of TGF-beta1 in HCC.
|
20038433 |
2010 |
|
Cachexia
|
0.340 |
Biomarker
|
phenotype |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Cachexia
|
0.340 |
Biomarker
|
phenotype |
CTD_human |
A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells.
|
12756304 |
2003 |
|
Cachexia
|
0.340 |
Biomarker
|
phenotype |
BEFREE |
Mice deficient in TTP and TNFR1, or in TTP and both receptors, were protected from developing the TNF-alpha-induced cachexia and inflammation.
|
11588035 |
2001 |
|
Dermatitis
|
0.310 |
Biomarker
|
disease |
BEFREE |
Mice deficient of TTP (TTP(-/-)) develop a systemic autoimmune inflammatory syndrome characterized by cachexia, conjunctivitis, and dermatitis.
|
23997224 |
2013 |
|
Dermatitis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Polyarthritis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.
|
15944294 |
2005 |
|
Polyarthritis
|
0.310 |
Biomarker
|
disease |
BEFREE |
This activity was discovered after TTP-deficient mice were created and found to have a systemic inflammatory syndrome with severe polyarticular arthritis and autoimmunity, as well as medullary and extramedullary myeloid hyperplasia.
|
15535838 |
2004 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results suggested that CRT could promote ICAM-1 expression in endothelial cells through PI3K/Akt/eNOS/p38 MAPK signaling mediated TTP accumulation, probably in an inactive form, which may provide a possible proinflammatory mechanism of CRT in RA.
|
30639474 |
2019 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
BEFREE |
TTP knockdown potentiated cytokine production in RA FLS and murine fibroblasts, which in the latter case was insensitive to inhibition by ITF2357 treatment.
|
30029685 |
2018 |
|
Rheumatoid Arthritis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TTP expression was significantly higher in RA than non-inflamed synovium, detected in macrophages, vascular endothelial cells and some fibroblasts and co-localised with MAPK p38 activation.
|
27597652 |
2017 |