ZFP36, ZFP36 ring finger protein, 7538

N. diseases: 161; N. variants: 3
Disease: Cachexia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia 		0.340 Biomarker phenotype BEFREE Mice deficient of TTP (TTP(-/-)) develop a systemic autoimmune inflammatory syndrome characterized by cachexia, conjunctivitis, and dermatitis. 23997224 2013
CUI: C0006625
Disease: Cachexia
Cachexia 		0.340 Biomarker phenotype BEFREE TTP(-/-) mice spontaneously develop an inflammatory syndrome characterized by cachexia, myeloid hyperplasia, dermatitis, and erosive arthritis. 23940256 2013
CUI: C0006625
Disease: Cachexia
Cachexia 		0.340 Biomarker phenotype BEFREE TTP-deficient (knockout [KO]) mice exhibit an early-onset, severe inflammatory phenotype, with cachexia, erosive arthritis, left-sided cardiac valvulitis, myeloid hyperplasia, and autoimmunity, which can be prevented by injections of anti-TNF Abs, or interbreeding with TNF receptor-deficient mice. 22491258 2012
CUI: C0006625
Disease: Cachexia
Cachexia 		0.340 Biomarker phenotype CTD_human Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function. 15944294 2005
CUI: C0006625
Disease: Cachexia
Cachexia 		0.340 Biomarker phenotype CTD_human A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. 12756304 2003
CUI: C0006625
Disease: Cachexia
Cachexia 		0.340 Biomarker phenotype BEFREE Mice deficient in TTP and TNFR1, or in TTP and both receptors, were protected from developing the TNF-alpha-induced cachexia and inflammation. 11588035 2001