Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression. 19781653 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology. 20226536 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. 21078228 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASDB Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression. 21676128 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE We were interested whether this also applies for ANK3 and CACNA1C and tested associations of single nucleotide polymorphisms (SNPs) in these genes with MDD in two Caucasian case-control samples. 22647524 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese. 23680436 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASDB A mega-analysis of genome-wide association studies for major depressive disorder. 22472876 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Genetic variation in CACNA1C affects neural processing in major depression. 24612926 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression. 23860750 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Genetic variation in CACNA1C affects neural processing in major depression. 24612926 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE Our study provides support for positive association between CACNA1C and MDD; however, the current data suggest the necessity of replication analyses in a larger-scale sample. 27260792 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder. 28497380 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5). 28989100 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease CTD_human Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. 28696432 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. 28696432 2018