Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASDB A mega-analysis of genome-wide association studies for major depressive disorder. 22472876 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASCAT Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. 30626913 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Genetic variation in CACNA1C affects neural processing in major depression. 24612926 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Genetic variation in CACNA1C affects neural processing in major depression. 24612926 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder. 28497380 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese. 23680436 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASDB Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE Our study provides support for positive association between CACNA1C and MDD; however, the current data suggest the necessity of replication analyses in a larger-scale sample. 27260792 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression. 19781653 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. 21078228 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease CTD_human Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. 28696432 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. 28696432 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression. 21676128 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression. 23860750 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 GeneticVariation disease BEFREE The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology. 20226536 2010
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker disease BEFREE These data suggest a role for MAPK1 and CACNA1C in MDD risk and treatment resistance, respectively. 31352702 2019