Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker disease BEFREE The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. 30902660 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker disease BEFREE Our data suggest that the tested CACNA1C SNPs may have impacts on cognitive recovery from depression. 28765577 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 GeneticVariation disease BEFREE Genome-wide association studies have identified allelic variation in CACNA1C as a risk factor for multiple psychiatric disorders associated with limbic system dysfunction, including bipolar disorder, schizophrenia, and depression. 26401721 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker disease PSYGENET Here, we aimed to assess how recently associated PCLO and CACNA1C depression risk alleles jointly affect memory-related CG25 activity as an intermediate phenotype in clinically healthy humans. 24643163 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 GeneticVariation disease BEFREE Here, we aimed to assess how recently associated PCLO and CACNA1C depression risk alleles jointly affect memory-related CG25 activity as an intermediate phenotype in clinically healthy humans. 24643163 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker disease PSYGENET Genetic variation in CACNA1C have also been associated with depression, schizophrenia, autism spectrum disorders, as well as changes in brain function and structure in control subjects who have no diagnosable psychiatric illness. 22705413 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 GeneticVariation disease BEFREE Genetic variation in CACNA1C have also been associated with depression, schizophrenia, autism spectrum disorders, as well as changes in brain function and structure in control subjects who have no diagnosable psychiatric illness. 22705413 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker disease PSYGENET Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis. 20723887 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 GeneticVariation disease BEFREE Caucasian non-Hispanic participants in the STAR*D study of treatment for depression for whom DNA was available (N = 1213) were genotyped at two single-nucleotide polymorphisms (SNPs) (rs10848635 and rs1006737) in the CACNA1C gene. 19388002 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 GeneticVariation disease BEFREE No indication for association to depression was found for P2RX7:2230912 and CACNA1C:rs1006737 without or with consideration of childhood problems or negative life events. 20226536 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker disease PSYGENET No indication for association to depression was found for P2RX7:2230912 and CACNA1C:rs1006737 without or with consideration of childhood problems or negative life events. 20226536 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 Biomarker disease PSYGENET Caucasian non-Hispanic participants in the STAR*D study of treatment for depression for whom DNA was available (N = 1213) were genotyped at two single-nucleotide polymorphisms (SNPs) (rs10848635 and rs1006737) in the CACNA1C gene. 19388002 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.380 GeneticVariation disease BEFREE Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis. 20723887 2010