Psychotic Disorders
|
0.500 |
Biomarker
|
group |
BEFREE |
The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function.
|
30079586 |
2019 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This included an association between the rs2007044 (risk allele G) within CACNA1C and poorer working memory performance (increased errors B (95% CI)=0.635-4.535, p=0.012), an effect driven mainly by the psychosis groups.
|
28607492 |
2017 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
Psychotic Disorders
|
0.500 |
Biomarker
|
group |
BEFREE |
Further study of CACNA1C using intermediate phenotypes for psychosis will determine the mechanisms by which variation in this gene confers risk.
|
26048451 |
2016 |
Psychotic Disorders
|
0.500 |
Biomarker
|
group |
PSYGENET |
Impaired reward processing may be a transdiagnostic phenotype of variation in CACNA1C that could contribute to anhedonia and other clinical features common to both affective and psychotic disorders.
|
25290268 |
2014 |
Psychotic Disorders
|
0.500 |
Biomarker
|
group |
PSYGENET |
The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder.
|
24262814 |
2014 |
Psychotic Disorders
|
0.500 |
Biomarker
|
group |
PSYGENET |
Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia.
|
24642287 |
2014 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated.
|
24461634 |
2014 |
Psychotic Disorders
|
0.500 |
Biomarker
|
group |
BEFREE |
The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder.
|
24262814 |
2014 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Impaired reward processing may be a transdiagnostic phenotype of variation in CACNA1C that could contribute to anhedonia and other clinical features common to both affective and psychotic disorders.
|
25290268 |
2014 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Hippocampal and frontolimbic function as intermediate phenotype for psychosis: evidence from healthy relatives and a common risk variant in CACNA1C.
|
24411473 |
2014 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
GWASDB |
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
|
24280982 |
2014 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia.
|
24642287 |
2014 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.
|
21767209 |
2011 |
Psychotic Disorders
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |