Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 Biomarker group BEFREE The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function. 30079586 2019
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE This included an association between the rs2007044 (risk allele G) within CACNA1C and poorer working memory performance (increased errors B (95% CI)=0.635-4.535, p=0.012), an effect driven mainly by the psychosis groups. 28607492 2017
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ. 27790829 2017
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 Biomarker group BEFREE Further study of CACNA1C using intermediate phenotypes for psychosis will determine the mechanisms by which variation in this gene confers risk. 26048451 2016
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 Biomarker group PSYGENET Impaired reward processing may be a transdiagnostic phenotype of variation in CACNA1C that could contribute to anhedonia and other clinical features common to both affective and psychotic disorders. 25290268 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 Biomarker group PSYGENET The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder. 24262814 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 Biomarker group PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated. 24461634 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 Biomarker group BEFREE The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder. 24262814 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE Impaired reward processing may be a transdiagnostic phenotype of variation in CACNA1C that could contribute to anhedonia and other clinical features common to both affective and psychotic disorders. 25290268 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE Hippocampal and frontolimbic function as intermediate phenotype for psychosis: evidence from healthy relatives and a common risk variant in CACNA1C. 24411473 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group GWASDB Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. 24280982 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287 2014
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype. 21767209 2011
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders
0.500 GeneticVariation group BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. 21078228 2011