|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genes Involved in Neurodevelopment, Neuroplasticity and Major Depression: No Association for <i>CACNA1C, CHRNA7</i> and <i>MAPK1</i>.
|
31352702 |
2019 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression.
|
28696432 |
2018 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5).
|
28989100 |
2018 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder.
|
28497380 |
2017 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia.
|
24642287 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Genetic variation in CACNA1C affects neural processing in major depression.
|
24612926 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in CACNA1C affects neural processing in major depression.
|
24612926 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.
|
24262814 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.
|
24262814 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression.
|
23860750 |
2014 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia.
|
24411473 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples.
|
22647524 |
2012 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology.
|
20226536 |
2010 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |