AHNAK, AHNAK nucleoprotein, 79026

N. diseases: 60; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2011
Conventional (Clear Cell) Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2011
CUI: C1266042
Disease: Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2011
CUI: C1266043
Disease: Sarcomatoid Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2011
Collecting Duct Carcinoma of the Kidney
0.300 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2011
CUI: C1306837
Disease: Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2011
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness
0.300 Biomarker phenotype CTD_human Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. 20388789 2010
CUI: C0263454
Disease: Chloracne
Chloracne
0.300 Biomarker disease CTD_human Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. 17101203 2007
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.210 Biomarker group RGD This is the first report that AHNAK can be targeted by the immune system in autoimmune disease. 11866458 2002
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.210 Biomarker group BEFREE This is the first report that AHNAK can be targeted by the immune system in autoimmune disease. 11866458 2002
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio
0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio
0.100 GeneticVariation phenotype GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
CUI: C0018498
Disease: Hair Color
Hair Color
0.100 GeneticVariation phenotype GWASCAT Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability. 30531825 2018
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio
0.100 GeneticVariation phenotype GWASCAT Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors. 30575882 2018
CUI: C0016529
Disease: Forced expiratory volume function
Forced expiratory volume function
0.100 GeneticVariation phenotype GWASCAT Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. 28166213 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.100 GeneticVariation disease GWASCAT Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. 26830138 2016
CUI: C0005893
Disease: Body mass index procedure
Body mass index procedure
0.100 GeneticVariation phenotype GWASDB Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. 19584900 2010
CUI: C0578022
Disease: Finding of body mass index
Finding of body mass index
0.100 GeneticVariation phenotype GWASDB Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. 19584900 2010
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 AlteredExpression phenotype BEFREE IMPLICATIONS: BRD4 functions as the dominant regulator of CRPC cell migration and invasion through direct transcriptional regulation of AHNAK, which together offer a novel targetable pathway to treat metastatic CRPC.<b>Visual Overview:</b> http://mcr.aacrjournals.org/content/molcanres/17/8/1627/F1.large.jpg. 31110158 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE The role of AHNAK in cancer is however unclear as the protein has previously been described as a tumor suppressor, as well as being essential for tumor metastasis and invasion, while also being implicated in selected chemotherapeutic responses. 29309757 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE Overall, our data indicate the efficacy of FRAEM and reveal a role of TmeA during chlamydial invasion that manifests independently of effects on AHNAK. 28970272 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer. 28494797 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 AlteredExpression phenotype BEFREE Through over expression of AHNAK in both of U87 and U251, we demonstrated that overexpression of AHNAK could inhibit glioma cell proliferation and invasion, induce apoptosis, and inhibit in vivo glioma tumor growth and ki-67 expression. 28928883 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.070 Biomarker phenotype BEFREE Since AHNAK is involved in cell migration and invasion in other metastatic tumor cells, we conducted migration and invasion assays in mesothelioma cell lines. 24253341 2014