NEIL1, nei like DNA glycosylase 1, 79661

N. diseases: 59; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease CTD_human In the current study, we report that exposure to a chronic oxidative stress in the form of a high-fat diet greatly accelerates the development of obesity in neil1(-/-) mice. 21285402 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C0028754
Disease: Obesity
Obesity 		0.500 Biomarker disease MGD The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.310 Biomarker disease CTD_human Extrapolation of these data suggests that individuals who are heterozygous for these inactive variant neil1 alleles may be at increased risk for metabolic syndrome. 17389588 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.310 GeneticVariation disease BEFREE Extrapolation of these data suggests that individuals who are heterozygous for these inactive variant neil1 alleles may be at increased risk for metabolic syndrome. 17389588 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.310 Biomarker disease CTD_human These data suggest an important role for NEIL1 in the prevention of the diseases associated with the metabolic syndrome. 16446448 2006
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker disease CTD_human Following a 5-wk high-fat diet challenge, neil1(-/-) mice gained significantly more body weight than neil1(+/+) littermates and had increased body fat accumulation and moderate to severe hepatic steatosis. 21285402 2011
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia 		0.300 Biomarker disease CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.300 Biomarker phenotype CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.300 Biomarker phenotype CTD_human A long-term high-fat diet also induced glucose intolerance as well as a significant reduction in mitochondrial DNA and protein content in neil1(-/-) mice. 21285402 2011
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Biomarker phenotype CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C1706412
Disease: Lipidemias
Lipidemias 		0.300 Biomarker phenotype CTD_human Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. 21285402 2011
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.300 Biomarker disease CTD_human Following a 5-wk high-fat diet challenge, neil1(-/-) mice gained significantly more body weight than neil1(+/+) littermates and had increased body fat accumulation and moderate to severe hepatic steatosis. 21285402 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.300 Biomarker disease CTD_human In the absence of exogenous oxidative stress, neil1 knockout (neil1-/-) and heterozygotic (neil1+/-) mice develop severe obesity, dyslipidemia, and fatty liver disease and also have a tendency to develop hyperinsulinemia. 16446448 2006
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.300 Biomarker group CTD_human In the absence of exogenous oxidative stress, neil1 knockout (neil1-/-) and heterozygotic (neil1+/-) mice develop severe obesity, dyslipidemia, and fatty liver disease and also have a tendency to develop hyperinsulinemia. 16446448 2006
CUI: C0598784
Disease: Dyslipoproteinemias
Dyslipoproteinemias 		0.300 Biomarker phenotype CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C1257963
Disease: Endogenous Hyperinsulinism
Endogenous Hyperinsulinism 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C1257964
Disease: Exogenous Hyperinsulinism
Exogenous Hyperinsulinism 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.300 Biomarker disease CTD_human The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. 16446448 2006
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker disease MGD
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 GeneticVariation group BEFREE We suggest that individuals who harbor the G83D NEIL1 variant face an increased risk for human cancer. 29156764 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 GeneticVariation group BEFREE We suggest that individuals who harbor the G83D NEIL1 variant face an increased risk for human cancer. 29156764 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 AlteredExpression group BEFREE As a mechanism underlying the reduced expression of NEIL1 in cancer, the epigenetic silencing of NEIL1 through promoter hypermethylation was found. 27042257 2016