PSCA, prostate stem cell antigen, 8000

N. diseases: 111; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group BEFREE In vivo trafficking of <sup>89</sup>Zr-oxine-labeled CAR T cells was evaluated in 2 murine xenograft tumor models: glioblastoma brain tumors with intracranially delivered IL13Rα2-targeted CAR T cells, and subcutaneous prostate tumors with intravenously delivered prostate stem cell antigen (PSCA)-targeted CAR T cells. 29728514 2018
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group BEFREE With respect to prostate cancer, prostatic acid phosphatase, prostate‑specific antigen, prostate‑specific membrane antigen (PSMA), prostate stem cell antigen, T‑cell receptor γ alternate reading frame protein, transient receptor potential‑p8 and six‑transmembrane epithelial antigen of the prostate 1 are among the identified target antigens for prostate tumors. 30542701 2018
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group BEFREE We also demonstrated that immunization of mice with the bivalent vaccine (Ad<sub>5</sub>-PSA+PSCA) inhibited the growth of established prostate tumors. 28939158 2017
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group BEFREE The in vivo tumor growth study showed that immunization of mice with Ad5-PSA/PSCA vaccine induced strong antitumor immunity when challenged with mouse prostate tumor cell lines (RM11) expressing human PSA (RM11/PSA). 21668311 2011
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 AlteredExpression group LHGDN Prostate stem cell antigen (PSCA) mRNA expression in prostatic intraepithelial neoplasia: implications for the development of prostate cancer. 17503471 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group LHGDN Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells. 17492652 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group LHGDN Prostate stem cell antigen is overexpressed in prostate cancer metastases. 15814638 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group CTD_human Complete androgen ablation suppresses prostate stem cell antigen (PSCA) mRNA expression in human prostate carcinoma. 16015594 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 AlteredExpression group BEFREE Mouse PSCA (mPsca) shares 65% homology with human PSCA at the nucleotide and amino acid levels. mRNA expression of mSteap and mPsca is largely prostate-specific and highly detected in primary prostate tumors and metastases of TRAMP mice. 11479226 2001