PSCA, prostate stem cell antigen, 8000

N. diseases: 111; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE Overall, significant association was observed between the PSCA gene variant rs2294008 polymorphism and bladder cancer (T vs C: OR = 1.16, 95%CI = 1.12-1.20; TT vs CC: OR = 1.32, 95%CI = 1.24-1.41; TT vs CT+CC: OR = 1.15, 95%CI = 1.09-1.22; TT+CT vs CC: OR = 1.27, 95%CI = 1.21-1.34). 31008939 2019
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE In conclusion, this study provides summary evidence that variants in the PSCA gene are associated with risk of gastric and bladder cancer, gastritis, as well as duodenal and gastric ulcer and highlights the significant role of this gene in the pathogenesis of these diseases. 30407486 2019
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer. 28881685 2017
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. 27001215 2016
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. 26308216 2015
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE Three previously established bladder cancer risk-associated SNPs (rs798766 in TACC3, rs9642880 in MYC, and rs2294008 in PSCA) were genotyped in 1,210 bladder cancer patients and 1,008 control subjects in Shanghai, China. 24155119 2014
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development. 25117309 2014
Malignant neoplasm of urinary bladder
0.500 AlteredExpression disease BEFREE PSCA is upregulated in prostate cancer, pancreatic cancer and bladder cancer, as well as a number of others, making it an ideal clinical target for both diagnosis and therapy. 24308679 2014
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity. 25374226 2014
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE Recently, two of the UBC risk variants (PSCA and UGT1A) were confirmed to have functional consequences. 23752272 2013
Malignant neoplasm of urinary bladder
0.500 Biomarker disease BEFREE Future clinical studies will be needed to validate PSCA as a therapeutic target for bladder cancer. 23266392 2013
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE Heterozymous and homozygous carriers of the SNP rs22940008 in the first exon of the PSCA gene are at increased risk for invasive bladder cancers. 23330817 2013
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors. 22416122 2012
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE We constructed a bladder cancer-specific adenovirus carrying E1A-androgen receptor (AR) under the control of UPII promoter and prostate stem cell antigen enhancer (PSCAE), designated as Ad/PSCAE/UPII/E1A-AR, and investigated its antitumor effects in vitro and in vivo. 22218302 2012
Malignant neoplasm of urinary bladder
0.500 Biomarker disease BEFREE Recent exciting findings that genetic variations of PSCA conferred increased risks of gastric cancer and bladder cancer have opened up a new avenue of research about the pathological function of PSCA. 20501618 2010
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease GWASDB A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. 20972438 2010
Malignant neoplasm of urinary bladder
0.500 Biomarker disease BEFREE Growth delay of human bladder cancer cells by Prostate Stem Cell Antigen downregulation is associated with activation of immune signaling pathways. 20374648 2010
Malignant neoplasm of urinary bladder
0.500 Biomarker disease CTD_human These results indicated that the rs2294008 polymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations. 20083643 2010
Malignant neoplasm of urinary bladder
0.500 Biomarker disease BEFREE Prostate stem cell antigen enhancer and uroplakin II promoter based bladder cancer targeted tissue-specific vector. 18440837 2010
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE These results indicated that the rs2294008 polymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations. 20083643 2010
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease GWASDB A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. 19648920 2009
Malignant neoplasm of urinary bladder
0.500 GeneticVariation disease BEFREE A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. 19648920 2009
Malignant neoplasm of urinary bladder
0.500 Biomarker disease CTD_human A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. 19648920 2009
Malignant neoplasm of urinary bladder
0.500 AlteredExpression disease BEFREE These data demonstrate that PSCA is overexpressed in a majority of human TCCs, particularly CIS and superficial tumors, and may be a useful target for bladder cancer diagnosis and therapy. 11406532 2001
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer
0.460 GeneticVariation disease BEFREE PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18-1.51; P=2.28×10<sup>-6</sup>) for the risk of DU. 31839644 2019