|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested ASNase wild-type (ASNase<sup>WT</sup>) and its glutaminase-deficient Q59L mutant (ASNase<sup>Q59L</sup>) and found that ASNase glutaminase activity contributed to durable anticancer activity against xenografts of the ASNS-negative Sup-B15 leukemia cell line in NOD/SCID gamma mice, whereas asparaginase activity alone yielded a mere growth delay.
|
31209181 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
L-asparaginase is a valuable protein therapeutic drug utilized for the treatment of leukemia and lymphomas.
|
30426897 |
2019 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Inhibition of autophagy by hydroxychloroquine, a well-tolerated autophagy inhibitor, reduced cell viability in both ETV6-RUNX1-positive cell lines and primary acute lymphoblastic leukemia samples, and selectively sensitized primary ETV6-RUNX1-positive leukemia samples to L asparaginase.
|
30381299 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, L-asparaginase (used for the treatment of Leukemia and for acrylamide reduction in food industries) and cellulase (useful for biofuel production and other industrial applications) have been identified for the first time in this species, giving new insights into possible biotechnological applications of dinoflagellates.
|
28916825 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are two major applications of l-asparaginase (L-ASNase): leukemia therapy and the food industry.
|
28505420 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similar to glutamine starvation, inhibition of glutamine metabolism with a chemical inhibitor currently under clinical evaluation was synthetically lethal with chloroquine and L-asparaginase, drugs approved for the treatment of malaria and leukemia, respectively.
|
28424408 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results of the study give leads for the anticancer effects of fungal l-asparaginase and its potential usefulness in the chemotherapy of leukemia.
|
27885727 |
2017 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glutaminase activity was not detected in the recombinant l-asparaginase, which could reduce the probable side effects during leukaemia therapy.
|
27155523 |
2016 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This drug combination warrants further investigation for use in the treatment of patients with ara-C and/or ASNase refractory leukemias.
|
12168812 |
2002 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro studies have demonstrated an adaptive increase in asparagine synthetase (AS) expression in ASNase-resistant cells, which is believed to permit ASNase-resistant human leukaemia cells to survive in vivo.
|
11485552 |
2001 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression was compared between different types of leukemia and was studied in relation with clinical risk indicators and in vitro cytotoxicity of the MDR-related drugs daunorubicin (DNR), vincristine (VCR), and etoposide (VP16) and the non-MDR-related drugs prednisolone (PRD) and L-asparaginase (ASP).
|
9490695 |
1998 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone.
|
6454771 |
1981 |