Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.
|
31009812 |
2019 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate.
|
31009812 |
2019 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous genome-wide association study observed that rs401681 within CLPTM1L (CLPTM1 like) was significantly associated with lung cancer.
|
29939218 |
2018 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Fine mapping in TERT-CLPTM1L region identified three independent lung cancer susceptibility signals: A large-scale multi-ethnic population study.
|
29809284 |
2018 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Individuals, including the smoking population, who carry both the TERT rs2736098 and CLPTM1L rs401681 T alleles are more likely to develop lung cancer.
|
28789383 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as plausible causative locus for lung cancer development.
|
27982019 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
|
28604730 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that certain CLPTM1L polymorphisms are protective factors against lung cancer in a southern Chinese Han population and may be potential diagnostic and molecular markers for lung cancer patients.
|
26852039 |
2016 |
Carcinoma of lung
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry was used to examine CLPTM1L expression levels on a tissue microarray containing 73 sets of human lung cancer specimens with adjacent normal tissue.
|
27062701 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The differences in risk level between Israeli Jews and non-Jews could not be explained by lung cancer genetic risk variants which were identified in GWAS (genes in the CHRNA5, TERT and CLPTM1L regions).
|
25924736 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The long TL genetic score was significantly associated with increased risk of lung adenocarcinoma (P = 6.3 × 10(-15)), even after exclusion of a SNP residing in a known lung cancer susceptibility region (TERT-CLPTM1L) P = 6.6 × 10(-6)).
|
26138067 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study examined associations between five single nucleotide polymorphisms (SNPs) of TERT-CLPTM1L (rs402710, rs401681, rs465498, rs4975616, and rs2736100) and lung cancer in a Chinese Han population in the Hubei Province.
|
25966219 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We observed statistically significant associations with melanoma for two lung cancer SNPs in the TERT-CLPTM1L locus (Bonferroni-corrected p<2.8x10-4), replicating known pleiotropic effects at this locus.
|
25789475 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that genetic variants of CLPTM1L contribute to lung cancer susceptibility in the northwest Chinese Han population.
|
25526467 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variant in CLPTM1L confers reduced risk of lung cancer: a replication study in Chinese and a meta-analysis.
|
25422207 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results of the present study suggest a potential association between CLPTM1L variants and lung cancer risk in the Chinese Han populations.
|
25155038 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, the joint effect of TERT and CLPTM1L variants increased the risk of lung cancer, especially squamous cell carcinoma, with an adjusted OR of 3.274.
|
24861918 |
2014 |
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
The risk genotype at the CLPTM1L locus was associated with high expression of CLPTM1L in normal lung tissue, suggesting that cis-regulation of CLPTM1L may contribute to lung cancer risk.
|
24366883 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies.
|
24907075 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis provides supportive evidence that CRR9p polymorphism may influence a risk of LC and NSCLC in a protective model.
|
24957041 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic receptor related genes (CHRNB3, CHRNA6, and CHRNA5/A3/B4) previously reported to be associated with lung cancer risk and smoking behavior and 14 SNPs in the four 'control' genes (TERT, CLPTM1L, CYP1A1, and TP53), which were not reported in the smoking GWA studies.
|
25233467 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in TERT-CLPTM1L genes and risk of lung cancer in a Chinese population.
|
24761905 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations.
|
24634236 |
2014 |