Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 Biomarker disease BEFREE Clinically, ANXA3 expression correlated positively with the autophagic marker LC3B in HCC and was associated with a worse overall survival in patients who went on to receive sorafenib treatment. 29885413 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 AlteredExpression disease BEFREE In addition, an inverse association between the expression of G9A and LC3B was demonstrated in HCC tumor samples in the publically available GSE14520 dataset, which indicated that G9A may also have the potential to regulate MAP1LC3B expression in HCC tumor tissues. 29928350 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 Biomarker disease BEFREE Survival analysis showed that ULK1 expression were negatively correlated with PFS rather than OS in HCC patients (P=0.021), while LC3B were suggested to be negatively related with patients' PFS, However, Simultaneous high expression of ULK1 and LC3B had a poorer 5-year overall survival (OS) rate (P=0.002) and shorter 5-year progression free survival (PFS)(P=0.003), Further multivariate analysis revealed that the two combined biomarkers were independent factors to predict the prognosis of OS and PFS in all patients, while ULK1 alone or LC3B alone were only an independent predict factor for OS or PFS respectively. 29091866 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 AlteredExpression disease BEFREE In the present study, we demonstrated that LC3B protein expression levels were significantly increased in the residual hepatocellular carcinoma cells after radiofrequency ablation (RFA) treatment in vivo. 29749472 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 AlteredExpression disease BEFREE Tissue microarray-based immunohistochemistry was used to examine the expression of LC3B and another autophagy key regulator (Beclin-1) in 156 operable HCC patients. 25256671 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.060 AlteredExpression disease BEFREE We found that restoration of miR-100 expression resulted in accumulation of LC3B-II and decrease of p62 in hepatocellular carcinoma (HCC) cells, whereas antagonism of miR-100 reduced the level of LC3B-II. 25026290 2014