|
Asthma
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Our study found that variations in the TLR1 and TLR10 genes increased the asthma risk after bronchiolitis.
|
30924193 |
2019 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the association of TLR1 rs5743618 and TLR10 rs4129009 polymorphisms with asthma and asthma medication in 125 children aged 11-13 years.
|
28692144 |
2018 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Current asthma was more common (30%) in children with the variant AG or GG genotype in the TLR10 rs4129009 gene versus those who were homozygous for the major allele A (11%) (p = 0.03).
|
28592890 |
2017 |
|
Asthma
|
0.170 |
Biomarker
|
disease |
BEFREE |
Expression of toll-like receptor (TLR) 2 subfamily genes, including genes encoding TLR1, TLR2, TLR6 and TLR10, have been connected to allergy and asthma.
|
24112285 |
2013 |
|
Asthma
|
0.170 |
Biomarker
|
disease |
BEFREE |
Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma.
|
20444155 |
2010 |
|
Asthma
|
0.170 |
Biomarker
|
disease |
BEFREE |
The majority of studies published since 2004 have been genetic association studies in various clinical settings, which have found positive associations of single nucleotide polymorphisms in TLR2, TLR4, TLR6 and TLR10 with asthma or atopy, although the number of studies is small and the results not yet replicated.
|
16505608 |
2006 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk.
|
15201134 |
2004 |
|
Asthma
|
0.170 |
GeneticVariation
|
disease |
LHGDN |
Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk.
|
15201134 |
2004 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Peripheral Arterial Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.
|
27082954 |
2016 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum LDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Bronchiolitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Our study found that variations in the TLR1 and TLR10 genes increased the asthma risk after bronchiolitis.
|
30924193 |
2019 |
|
Bronchiolitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSION: Polymorphisms in both the TLR1 and TLR10 genes may increase the risk of asthma at 11-13 years after infant bronchiolitis.
|
28692144 |
2018 |
|
Bronchiolitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in the TLR10 gene increases and in the TLR7 gene may increase the risk of asthma in preschool-aged children after infant bronchiolitis.
|
28592890 |
2017 |
|
Bronchiolitis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
There were no significant associations between the genotypes or allele frequencies of TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and clinical characteristics or the severity of bronchiolitis during hospitalization.
|
27498757 |
2016 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Erratum to "Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis".
|
30983882 |
2019 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The present study reveals that enhanced TLR10 in B cell subsets is positively correlated with disease activity in RA subjects.
|
30686934 |
2018 |
|
Tuberculosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
There is evidence that TLR10, a TLR2 signaling modulator, may be involved in progression of tuberculosis (TB).
|
29527210 |
2018 |