CAPN1, calpain 1, 823

N. diseases: 165; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 AlteredExpression phenotype BEFREE The present results suggest that meat tenderness in Nellore cattle does not directly depend on the expression of the CAPN1 and CAPN2 genes, but is associated with the expression of other genes such as CAST2, HSP90AA1, DNAJA1 and HSPB1. 29331838 2018
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 AlteredExpression phenotype BEFREE The improved tenderness in both prime and bull meat was associated with a lower myofibrillar fragmentation index and reduced calpain 1 activity which indicated the mechanism of tenderisation was different from that which occurred in chill aged meat. 29751219 2018
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 Biomarker phenotype BEFREE EB- or XR-irradiated samples showed slower autolysis of calpain-1; however, beef tenderness was not affected. 29107867 2018
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 GeneticVariation phenotype BEFREE Our results indicate that both calpain-1 and calpain-2 may contribute to the postmortem improvement of beef tenderness, with calpain-1 being responsible for the tenderness improvement early postmortem and calpain-2 responsible for additional tenderization during extended aging. 28527364 2017
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 Biomarker phenotype BEFREE The micromolar calcium activated neutral protease <i>(CAPN1)</i> and calpastatin <i>(CAST)</i> have been widely regarded as genes related to muscle growth and meat tenderness. 28713829 2017
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 GeneticVariation phenotype BEFREE Single nucleotide polymorphisms (SNPs) carried in calpain (CAPN1), calpastatin (CAST), and leptin (LEP) genes are associated with meat tenderness. 28525658 2017
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 GeneticVariation phenotype BEFREE Combining beef cattle data identified correlated SNPs representing CAPN1 (chr29:44 M+) and CAST (chr 7:96 M+) loci affecting beef tenderness, showing pleiotropic effects in dairy cattle. 28835686 2017
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 GeneticVariation phenotype BEFREE The objective of this study was to evaluate the effects of seven single nucleotide polymorphisms (SNPs) in Calpain 1 and Calpastatin genes previously associated with meat tenderness attributes in other cattle breeds in Korean Hanwoo cattle. 24468663 2014
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 GeneticVariation phenotype BEFREE Two favorable CAPN1-4751 alleles increased tenderness of AT-striploin, TS-striploin, and rump steaks by 6.5, 4.3, and 3.9 units, and overall liking by 5.6, 3.1, and 4.1 units. 22367069 2012
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 Biomarker phenotype BEFREE Muscle color and marbling were affected by CAPN1 316 and E2FB and Warner-Bratzler meat tenderness by the former. 22818350 2012
CUI: C0234233
Disease: Sore to touch
Sore to touch
0.100 Biomarker phenotype BEFREE The eight SNP, which were located within five genes: mu-calpain (CAPN1), calpastatin (CAST), leptin (LEP), growth hormone receptor (GHR) and acylCoA:diacylglycerol acyltransferase 1 (DGAT1), are included in various commercial tests for tenderness, fatness, carcass composition and milk yield/quality. 19555501 2009