|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A screening method optimized to discover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that share common leukemogenic pathways.
|
30670779 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice.
|
31141090 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we demonstrate that the Polycomb Repressive Complex 1 gene BMI1 is consistently overexpressed in adult and pediatric CALM-AF10-positive leukemias.
|
31022428 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings uncover a novel mechanism of leukemogenesis mediated by the nuclear export pathway and support further investigation of the utility of nuclear export inhibitors as therapeutic agents for patients with CALM-AF10 leukemias.
|
23487024 |
2013 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AF10 is a transcription factor that has been implicated in the development of leukemia following chromosomal rearrangements between the AF10 gene and one of at least two other genes, MLL and CALM.
|
23284727 |
2012 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Leukemias induced by the CALM-AF10 (MF) mutant recapitulated multiple aspects of full-length CALM-AF10-induced leukemia, including aberrant Hoxa cluster upregulation, a characteristic molecular lesion of CALM-AF10 leukemias.
|
21681188 |
2011 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A total of 91% (10 of 11) of mice with Zeb2 insertions developed B-lineage acute lymphoblastic leukemia, suggesting that Zeb2 activation promotes the transformation of CALM-AF10 hematopoietic precursors toward B-lineage leukemias.
|
20007546 |
2010 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the long latency of leukemogenesis of CALM-AF10 transgenic mice suggests that the direct effects of fusion oncogene are not sufficient for the induction of leukemia.
|
19443658 |
2009 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
This review discusses the normal structure and function of CALM and AF10, describes the spectrum of clinical findings seen in patients with CALM-AF10 fusions, summarizes recently published CALM-AF10 mouse models and highlights the role of HOXA cluster gene activation in CALM-AF10 leukemia.
|
18094714 |
2008 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review discusses the normal structure and function of CALM and AF10, describes the spectrum of clinical findings seen in patients with CALM-AF10 fusions, summarizes recently published CALM-AF10 mouse models and highlights the role of HOXA cluster gene activation in CALM-AF10 leukemia.
|
18094714 |
2008 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of CALM/AF10 in primary murine bone marrow cells results in the development of an aggressive leukemia in a murine bone marrow transplantation model.
|
18037964 |
2008 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
The expression of CALM/AF10 in primary murine bone marrow cells results in the development of an aggressive leukemia in a murine bone marrow transplantation model.
|
18037964 |
2008 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
A novel AF10-CALM fusion transcript in gamma/delta-T cell type lymphoblastic lymphoma.
|
17597474 |
2007 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice.
|
17804713 |
2007 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Real-time quantitative polymerase chain reaction (RQ-PCR) analysis showed that the expression of the whole HOXA gene cluster was dramatically dysregulated in the HOXA-rearranged cases, and also in MLL and CALM-AF10-related T-ALL cases, strongly suggesting that HOXA genes are oncogenic in these leukemias.
|
15774621 |
2005 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CALM-AF10 fusion gene in leukemias: simple and inversion-associated translocation (10;11).
|
11106826 |
2000 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that fusion of CALM and AF10 is a recurring abnormality in both lymphoid and myeloid leukemias of various types including AML-M5, and that the breakpoints in the two types of leukemia do not differ.
|
10637483 |
2000 |
|
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization studies have demonstrated that AF10 and CALM are also involved in other hematological malignancies containing t(10;11)(p13;q21), but no data are available concerning the molecular details of AF10-CALM fusion in primary leukemias.
|
9737689 |
1998 |