AXIN2, axin 2, 8313

N. diseases: 169; N. variants: 34
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 Biomarker disease BEFREE miR-3120-5p promotes colon cancer stem cell stemness and invasiveness through targeting Axin2. 29307822 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 Biomarker disease BEFREE Finally, reprogrammed tumors enhance GLI2, and we show that GLI2(high) and AXIN2(low), which are markers of the metastatic transition of colon cancers, are prognostic of poor disease outcome in patients. 26031752 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 Biomarker disease BEFREE AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on. 25504512 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 GeneticVariation disease BEFREE The finding was reminiscent of a previously described family harboring an AXIN2 mutation which could be shown to segregate with both the tooth agenesis and the predisposition to colon cancer transmitted in this family. 24631698 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 Biomarker disease CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 GeneticVariation disease BEFREE Furthermore, AXIN2, a gene that when mutated increases susceptibility to colon cancer, also is associated with CL/P. 19119171 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 AlteredExpression disease BEFREE Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer. 15885887 2006
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 AlteredExpression disease BEFREE In 30 human cell lines derived from different origins, axin2 and hnkd were expressed only in human colon cancer cell lines that are known to have activating mutations in the Wnt/beta-catenin pathway. 11752446 2001
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 Biomarker disease HPO