Meningioma
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
BAP1-TPDS is associated with an increased risk of developing uveal melanoma (UM), cutaneous melanoma (CM), malignant mesothelioma (MMe), renal cell carcinoma (RCC), meningioma, cholangiocarcinoma, multiple non-melanoma skin cancers, and <i>BAP1</i>-inactivated nevi.
|
31382694 |
2019 |
Meningioma
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
KLF4 mutations are specific for secretory histology, and BAP1 alterations are common in progressive rhabdoid meningiomas.
|
30379704 |
2018 |
Meningioma
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
Although there have been reports of sarcomas and meningiomas in patients affected with BAP1 mutations, to our knowledge malignant peripheral nerve sheath tumors in this patient population have not been previously reported.
|
29061454 |
2018 |
Meningioma
|
0.690 |
Biomarker
|
disease |
BEFREE |
BAP1 (BRCA1-associated protein 1) is a tumor suppressor gene that is associated with multiple tumors, including rhabdoid meningiomas.
|
29981911 |
2018 |
Meningioma
|
0.690 |
Biomarker
|
disease |
BEFREE |
Patients with BAP1-negative rhabdoid meningiomas had reduced time to recurrence compared with patients with BAP1-retained rhabdoid meningiomas (Kaplan-Meier analysis, 26 mo vs 116 mo, P < .001; hazard ratio 12.89).
|
28170043 |
2017 |
Meningioma
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
Because BAP1-mutant meningiomas are rare tumors, multi-institutional efforts will be needed to evaluate therapeutic strategies and to further define the clinicopathologic features of these tumors.
|
28482042 |
2017 |
Meningioma
|
0.690 |
Biomarker
|
disease |
CTD_human |
Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area.
|
25231345 |
2015 |
Meningioma
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
We report a high-risk cancer family with multiple mesotheliomas, cutaneous melanomas, basal cell carcinomas, and meningiomas segregating with a germline nonsense mutation in BAP1 (c.1938T>A; p.Y646X).
|
26409435 |
2015 |
Meningioma
|
0.690 |
GeneticVariation
|
disease |
BEFREE |
Inactivating germ line BRCA1-associated protein-1 (BAP1) mutations have recently been reported in families with uveal or cutaneous malignant melanoma (UMM, CMM), mesothelioma, and meningioma.
|
22889334 |
2012 |
Meningioma
|
0.690 |
AlteredExpression
|
disease |
BEFREE |
Biallelic inactivation of BAP1 and decreased BAP1 expression were identified in the UM, lung adenocarcinoma and meningioma tumours from three family members with this germline BAP1 mutation.
|
21941004 |
2011 |
Meningioma
|
0.690 |
Biomarker
|
disease |
HPO |
|
|
|
Meningioma
|
0.690 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|