CASP3, caspase 3, 836

N. diseases: 819; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Significant increased activation of TNF-α, Caspase-3 activity and myocardial infarct size in DOX-treated group. 31630586 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE We showed that punicalagin-treated group exhibited enhanced cardiac function, reduced myocardial infarction and decreased cleaved caspase-3 level. 31063767 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE At the same time, NPY-knockout rats exhibited a remarkable decrease in infarct size, serum lactate dehydrogenase activity, cardiomyocyte apoptosis, and caspase-3 expression and activity and a strong improvement in heart contractile function compared with MI rats. 31708788 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE It was found that after miR-34a antagomir reversed FS (%) and EF (%) in MI rats, the messenger RNA (mRNA) and protein levels of Caspase-3 in Sham group and MI + miR-34a antagomir group were significantly lower than those in the MI group (p < 0.05), indicating that the addition of miR-34a antagomir inhibited myocardial cell apoptosis after infarction, while the mRNA and protein levels of Wnt/β-catenin were both higher than those in the MI group. 30964183 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Transplantation of cardiac Sca-1-positive cells rather than c-Kit-positive cells preserves mitochondrial oxygen consumption of the viable myocardium following myocardial infarction in rats. 31375326 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Also, terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling staining and the expression of cleaved caspase 3 suggested that MI-induced myocytes apotosis was inhibited by PTHrP 87 to 139. 30994964 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Furthermore, reconstitution of Sca-1 KO mice with WT Sca-1<sup>+</sup> cells was associated with the reactivation of EMT and improved cardiac function after MI. 29556355 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Caspase-3 activity was higher in the amygdala (medial and lateral) and hippocampal CA3 region in untreated MI rats, whereas caspase-6 activity was higher in the CA1 region. 30486235 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE <i>In vivo</i>, the MI mice exhibited worse cardiac function by echocardiographic assessment and showed larger myocardial scarring by light microscopy, whereas aliskiren treatment reversed these effects, which were also associated with the changes in caspase-3 and Bcl-2 expression as well as in the number of apoptotic cells. 29184499 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE MicroRNA-98 negatively regulates myocardial infarction-induced apoptosis by down-regulating Fas and caspase-3. 28784995 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic disease RGD Ad-HGF improves the cardiac remodeling of rat following myocardial infarction by upregulating autophagy and necroptosis and inhibiting apoptosis. 27904666 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease CTD_human Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis. 25450231 2015
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Erythropoietin administration after myocardial infarction reduced caspase 3 expression (apoptotic activity) and induced neovascularization around the infarct area. 23453036 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Kallikrein gene delivery improved cell survival parameters as shown by increased phospho-Akt and reduced caspase-3 activation at 2 weeks after MI. 12411458 2002