SPOP, speckle type BTB/POZ protein, 8405

N. diseases: 72; N. variants: 12
Disease: Renal carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.050 GeneticVariation disease BEFREE Mutations in SPOP and the resulting dysregulation of this proteostatic pathway play causative roles in the pathogenesis of prostate and endometrial cancers, whereas overexpression and mislocalization are associated with kidney cancer. 31495053 2019
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.050 Biomarker disease BEFREE However, SPOP has largely an oncogenic role in kidney cancer. 29128526 2018
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.050 Biomarker disease BEFREE Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer. 27622336 2016
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.050 Biomarker disease BEFREE SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. 24656772 2014
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.050 AlteredExpression disease BEFREE In humans, we found that SPOP plays a conserved role in TNF-mediated JNK signaling and was highly expressed in 99% of clear cell renal cell carcinomas (RCCs), the most prevalent form of kidney cancer. 19164706 2009