CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 Biomarker disease BEFREE Mixed bone marrow chimeric mice demonstrate that caspase-8 deficiency does not confer preferential expansion of synovial macrophage and dendritic cell populations, nor do caspase-8-deficient synovial populations succumb to RIPK3-mediated necroptotic death. 28978351 2017
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 GermlineCausalMutation disease ORPHANET Advances in autoimmune lymphoproliferative syndromes. 21447005 2011
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 Biomarker disease BEFREE FADD deficiency sensitized more efficiently for TNFR1-mediated necroptosis than caspase-8 deficiency pointing to a caspase-8 independent inhibitory activity of FADD on TNF-induced necroptosis. 30741924 2019
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 Biomarker disease MGD
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 GermlineCausalMutation disease ORPHANET Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome. 16446975 2006
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 GeneticVariation disease UNIPROT Thus, caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes. 12353035 2002
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 AlteredExpression disease BEFREE Studies of patients with autoimmune lymphoproliferative syndrome (ALPS) or caspase-8 deficiency state (CEDS) demonstrated the ability of gene expression microarray analyses and small interfering RNAs (siRNA) to establish the physiologically important roles of NRAS, caspase-10, and caspase-8 for normal lymphocyte apoptosis and activation. 18818883 2009
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 Biomarker disease BEFREE Thus, caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes. 12353035 2002
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 CausalMutation disease CLINVAR
Autoimmune Lymphoproliferative Syndrome Type 2B
0.940 Biomarker disease CTD_human
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE Adenovirus-mediated transfection of caspase-8 sensitizes hepatocellular carcinoma to TRAIL- and chemotherapeutic agent-induced cell death. 16750275 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 AlteredExpression disease BEFREE Our data demonstrate that HBV-associated HCC showed a common defect in the expression of Fas, upregulation of FAP and downregulation of downstream molecules such as FADD and FLICE. 10025875 1998
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease LHGDN P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes. 17224200 2007
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 CausalMutation disease CLINVAR
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE Moreover, loss of both Ripk1 and Traf2 in LPC not only resulted in caspase-8 hyperactivation but also impaired NF-κB activation, promoting the spontaneous development of hepatocellular carcinoma. 28017612 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE It suggests that PAK4 as target is a switch between caspase-8 apoptosis and NF-κB survival signals induced by TNF-α in hepatocarcinoma cells. 30149917 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 GeneticVariation disease BEFREE Also, the data suggest that caspase-8 gene mutation might lead to the loss of its cell death function and contribute to the pathogenesis of HCC. 15531912 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE Taken together, our results demonstrated that ASB3 can regulate mitochondrial pathway of apoptosis by controlling caspase-8 mediated cleavage of Beclin1 in HCC. 31016535 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE On the whole, the present study revealed a molecular link between the three‑miRNA signature, comprising miR‑371-5p, miR‑373 and miR‑543, and the negative necroptotic regulator Casp‑8, and presents evidence for its employment as a novel potential diagnostic, prognostic and therapeutic target in HCC. 29845207 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Therapeutic disease RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. 28898696 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. 15105837 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 AlteredExpression disease BEFREE In this study, we investigated caspase-8 expression in hepatocellular carcinomas (HCCs) using recently described HCC mouse models (c-myc and IgEGF transgenes). 16285959 2005
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE ANP32B knockdown by siRNA altered the expression of apoptosis-related proteins in HCC cell lines and reduced the expression of cleaved forms of caspase 3 and caspase 9, but not that of caspase 8, in HCC cells cultured with the pro-apoptotic agent staurosporine. 28486557 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker disease BEFREE We found that the oncolytic adenoviruses Ad·AFP·D55-IL-24 and Ad·AFP·D55-TRAIL express tumor-suppressor gene interleukin-24 (IL-24) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), respectively, significantly suppressed the HCC cell growth in vitro by inducing apoptosis by the caspase-8 and mitochondria-dependent caspase-9 signaling pathways. 21979578 2012