CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.230 Biomarker disease BEFREE Caspase-8 plays a key role in causing AD by cleaving amyloid precursor proteins during apoptosis leading to increased formation of the amyloid-beta peptide. 31354494 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.230 Therapeutic disease RGD Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ 29642617 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.230 Biomarker disease BEFREE As caspase inhibition has been proposed as a mechanism for AD treatment, our finding that AD-associated CASP8 variants reduce caspase function calls for caution and is an impetus for further studies on the role of caspases in AD and other neurodegenerative diseases. 28985224 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.230 Biomarker disease BEFREE Thus, a principal caspase pathway from caspase-8 to caspase-3 and/or 7 may contribute to neuron loss in AD brain. 16772874 2006