Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition, the present results indicate that TRAF2 affects TRAIL-induced apoptosis in prostate cancer DU-145 cells via regulating cleaved Caspase-8 and c-Flip expression.
|
28855498 |
2017 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC and breast cancer, is protective against prostate cancer [odds ratio (OR) = 0.91, P = 1.0 × 10(-6)]. rs700635[C] is also associated with failures to correctly splice out CASP8 intron 8 in breast and prostate tumours and in corresponding normal tissues.
|
26740556 |
2016 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The andean anticancer herbal product BIRM causes destabilization of androgen receptor and induces caspase-8 mediated-apoptosis in prostate cancer.
|
27705939 |
2016 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In our meta-analysis, ethnic-specific differences were evident in the association of CASP8 -625 6N del and D302H polymorphisms with PCa risk.
|
25292051 |
2014 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Carriers of either the CASP8 or the CASP10 variants were underrepresented in the prostate cancer series (P = 0.02).
|
21396839 |
2013 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that the CASP 8 IVS12-19G/A and CASP 9 -1263 polymorphism may be involved in etiology of CaP and thus could be implicated as a marker for genetic susceptibility in North Indian population.
|
21396853 |
2013 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we show that sHA is a potent inhibitor of prostate cancer. sHA blocked the proliferation, motility, and invasion of LNCaP, LNCaP-AI, DU145, and LAPC-4 prostate cancer cells, and induced caspase-8-dependent apoptosis associated with downregulation of Bcl-2 and phospho-Bad. sHA inhibited Akt signaling including androgen receptor (AR) phosphorylation, AR activity, nuclear factor κB (NFκB) activation, and VEGF expression.
|
21555367 |
2011 |
Prostate carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma.
|
20033885 |
2010 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition to activating the caspase-8-dependent extrinsic apoptosis pathway, we observed that Bcl-X(L) overexpression inhibited triterpenoid-mediated killing of prostate cancer cell line Du145, suggesting that the intrinsic pathway (via mitochondria) also participates in triterpenoid-mediated killing.
|
18413762 |
2008 |
Prostate carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We have examined caspase-8 activity, BID cleavage, Akt activity, mitochondrial membrane potential (DeltaPsi(m)) and apoptosis in prostate cancer (LNCap, PC-3, PC-3M and DU145) cells treated with or without TRAIL.
|
11593415 |
2001 |
Prostate carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Sulindac sulfide up-regulated DR5 and activated the proximal caspase 8 in various different colon and prostate cancer cell lines.
|
11559570 |
2001 |