CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 Biomarker group CTD_human A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 29915430 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 AlteredExpression group BEFREE The apoptosis of breast tumour cells induced by TRAIL is blocked at the level of apical activation of caspase-8 and SAHA enhances the TRAIL-induced processing of procaspase-8. 21107885 2012
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 GeneticVariation group LHGDN Evidences for association of the CASP8 -652 6N del promoter polymorphism with age at diagnosis in familial breast cancer cases. 18343995 2009
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 Biomarker group CTD_human A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. 17450141 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 GeneticVariation group LHGDN A common coding variant in CASP8 is associated with breast cancer risk. 17293864 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 Biomarker group CTD_human A common coding variant in CASP8 is associated with breast cancer risk. 17293864 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 Biomarker group LHGDN Impaired kinetics of Bax-GFP and Smac/DIABLO-GFP in caspase-8- and bid-silenced and Bcl-2 overexpressed breast cancer MCF-7 cells exposed to camptothecin. 17666167 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 AlteredExpression group LHGDN In breast tumor cells, apoptosis induction by TRAIL is blocked at the level of apical caspase-8 activation. 16951203 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 AlteredExpression group LHGDN HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. 14701762 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 AlteredExpression group LHGDN We have characterized the human caspase-8 gene promoter and studied the transcriptional regulation of caspase-8 gene expression in MCF-7 breast tumor cells treated with IFN-gamma. 14993214 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 GeneticVariation group LHGDN Association of a common variant of the CASP8 gene with reduced risk of breast cancer. 15601643 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.380 Biomarker group CTD_human Association of a common variant of the CASP8 gene with reduced risk of breast cancer. 15601643 2004