Bipolar Disorder
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
This differential expression of DARPP-32 and CaN may reflect potential molecular mechanisms underlying the pathogenesis of schizophrenia and bipolar disorder, or differences between these two major psychiatric diseases.
|
31619735 |
2019 |
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
We found that the expression of t-DARPP-32 was increased in the DLPFC of patients with schizophrenia and bipolar disorder, and was strongly associated with genotypes at SNPs (rs879606, rs90974 and rs3764352), as well as the previously identified 7-SNP haplotype related to cognitive functioning.
|
23295814 |
2014 |
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the association of expression of two major DARPP-32 transcripts, full-length (FL-DARPP-32) and truncated (t-DARPP-32), with genetic variants of DARPP-32 in three brain regions receiving dopaminergic input and implicated in schizophrenia (the dorsolateral prefrontal cortex (DLPFC), hippocampus and caudate) in a much larger set of postmortem samples from patients with schizophrenia, bipolar disorder, major depression and normal controls (>700 subjects).
|
23295814 |
2014 |
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
our data suggest: (i) C14ORF28, GNB2L1, MLLT3, DRD2 and DARPP-32 are important in the pathogenesis of schizophrenia and bipolar disorder; (ii) these two disorders share common disease-related mechanisms linked to dopamine signalling; (iii) the expression of these genes is closely correlated; and (iv) DRD2 provides the initial trigger in the pathogenesis of these disorders.
|
20874815 |
2011 |
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population.
|
18055181 |
2008 |
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
LHGDN |
Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population.
|
18055181 |
2008 |
Bipolar Disorder
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
We performed RT-PCR to quantify DARPP-32 mRNA from brain samples (Brodmann Area 46) donated by the Stanley Medical Research Institute (SMRI, Array Collection): 35 from unaffected controls (UC), 35 from patients with schizophrenia (SCZ), and 35 with bipolar disorder (BP).
|
18573638 |
2008 |
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population.
|
18055181 |
2008 |
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
We performed RT-PCR to quantify DARPP-32 mRNA from brain samples (Brodmann Area 46) donated by the Stanley Medical Research Institute (SMRI, Array Collection): 35 from unaffected controls (UC), 35 from patients with schizophrenia (SCZ), and 35 with bipolar disorder (BP).
|
18573638 |
2008 |
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
LHGDN |
The present study suggests that DARPP-32 decreases in the DLPFC of patients with schizophrenia and bipolar disorder, and further suggests that this decrease is associated with dysfunction of dopaminoceptive neurons in the DLPFC of patients affected by these two mental disorders.
|
17521792 |
2007 |