Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.050 Biomarker group BEFREE The use of transgenic mouse mammary tumor models to study Darpp-32 and t-Darpp in breast cancer in vivo has been limited by a lack of knowledge regarding t-Darpp expression in mice, in both normal and malignant tissue. 25128420 2014
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.050 AlteredExpression group BEFREE The immunohistochemistry analysis of DARPP-32/t-DARPP protein(s) expression in breast cancer tissue microarray that contained 59 tumors and matched normal tissues when available indicated overexpression in 35.5% of primary breast tumors that were more frequent in invasive ductal carcinomas (43.7%; 21/48). 20836878 2010
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.050 AlteredExpression group BEFREE Finally, we found that full-length DARPP-32 and t-Darpp are expressed in a majority of primary breast tumors. 19301121 2010
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.050 Biomarker group LHGDN Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells. 18579663 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.050 Biomarker group LHGDN Mutational substitution of the phosphorylation sites Thr-34 or Thr-75 on DARPP-32 revealed that phosphorylation of Thr-34 is necessary for the ability of DARPP-32 to impair breast tumor cell migration. 17027969 2006