CAT, catalase, 847

N. diseases: 794; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE The Safety and Efficacy of Anti-IL-13 Treatment with Tralokinumab (CAT-354) in Moderate to Severe Asthma: A Systematic Review and Meta-Analysis. 31152798 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Longitudinal data from the Kids-CAT study on children and adolescents with asthma, diabetes and juvenile arthritis (n = 248; aged 7-17 years) were assessed at three measurement points over six months. 29580563 2018
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Tralokinumab (CAT-354) is an IL-13-neutralising human IgG4 monoclonal antibody that has shown clinical benefit in patients with asthma. 27956146 2017
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The aim of this study was to examine the association of manganese superoxide dismutase (MnSOD) Ala16Val, catalase (CAT) A-21T and tumor necrosis factor alpha (TNF-α) G-308A polymorphisms with bronchial asthma. 25931357 2015
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The -262C>T and -21A>T polymorphisms in the CAT gene were genotyped in 493 individuals with asthma, 265 with COPD, and 1,076 healthy controls. 24824229 2014
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE These results suggest that catalase polymorphism might participate in development of bronchial asthma and in enhanced oxidative damage in asthmatic children. 23827365 2013
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE In this case study, we describe the use of in vitro protein evolution with ribosome display to improve the potency of a human interleukin-13-neutralising antibody by a factor of over 200-fold and derive a therapeutic candidate, CAT-354, for the treatment of asthma. 22094818 2012
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE In our study, we did not find a significant association between Mn-SOD Ala16Val, CAT C-262T and asthma. 21829032 2011
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE Notably, no association of CAT genotype -21AA with asthma was found in high fruit and vegetable consumers, whereas low fruit and vegetable consumers (one time per day or less often) possessing this genotype were at increased risk of both allergic (p = 0.013) and nonallergic (p = 0.008) asthma. 19373626 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE The individual effect of functional single nucleotide polymorphisms within the catalase and myeloperoxidase genes (CAT and MPO) has been studied in relation to asthma; however, their interrelationship with ambient air pollution exposures has yet to be determined. 19897513 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease CTD_human In contrast, Hispanic children with a variant of the CAT-262 "T" allele (CT or TT) had an increased risk for asthma (HR, 1.78; P value = 0.01). 18048809 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease LHGDN In contrast, Hispanic children with a variant of the CAT-262 "T" allele (CT or TT) had an increased risk for asthma (HR, 1.78; P value = 0.01). 18048809 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE In contrast, Hispanic children with a variant of the CAT-262 "T" allele (CT or TT) had an increased risk for asthma (HR, 1.78; P value = 0.01). 18048809 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The less frequent variant of catalase gene (-262T) was found to be protective from the development of asthma in a Hong Kong Chinese non-smoking population (adjusted odds ratio=0.35, 0.15-0.85; P=0.017). 16630148 2006
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE In an application to asthma case-control data from the Children's Health Study, FITF identified a significant multilocus effect between the nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase gene (NQO1), myeloperoxidase gene (MPO), and catalase gene (CAT) (unadjusted P = .00026), three genes that are involved in the oxidative stress pathway. 16385446 2006
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE Environmental lead exposure depresses the activities of a several enzyme systems that influence cellular reducing capacity (glucose-6-phosphate dehydrogenase, NAD synthetase, glutathione peroxidase, superoxide dismutase, catalase) and consequently may increase asthma risk. 8568107 1995