The aim of the present study was to evaluate the activity of antioxidant enzymes, such as superoxide dismutase (SOD; isoforms: Cu/ZnSOD and MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione S-transferase (GST), along with the concentration of malondialdehyde (MDA) in tumor and adjacent noncancerous tissues of two histological types of NSCLC, i.e., adenocarcinoma and squamous cell carcinoma, collected from 53 individuals with surgically resectable NSCLC.
To further delineate the extent of this deletion 28 NSCLCs were examined by high resolution deletion mapping for allelic loss at 11p13.95% (18/28) of the informative cases displayed allelic loss at the catalase gene locus (CAT), 64% (18/28) at D11S935 and D11S941E, respectively, and 23% (6/26) at D11S907.
The capacity of N-SCLC cells to reactivate pRSV-CAT plasmid damaged with cisplatin and transfected into cells was higher in N-SCLC cells than in SCLC cells originating from patients who were untreated previously (P < 0.05).