CAT, catalase, 847

N. diseases: 794; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE Both PPe and PPe-H could distinctly reduce fasting blood glucose level, prevent the weight loss in T2DM rats, and exhibited the remarkable ability to enhance the activities of the antioxidant enzymes (CAT and GR, p < 0.01, p < 0.01) and the level of GSH (p < 0.05, p < 0.01). 30267825 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE All meta-analysis' studies which assessed the association of single nucleotide polymorphisms of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX), glutathione S transferase (GST), nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate oxidase (NOX) with T2DM and its complications were systematically extracted from PubMed, Scopus and Web of Science databases up to January 2016. 28548478 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Interaction of SNPs <i>GSTM1</i>del, <i>GSTT1</i>del, <i>GSTP1</i> + 313A/G (105Ile/Val), <i>CAT</i>-21A/T, <i>SOD2</i> + 47C/T, <i>GPx1</i> + 599C/T were significantly linked with disease risk >5 × 10<sup>3</sup> fold.<b>Conclusion</b>: As the number of gene combinations increase, there is a rise in the odds ratio of disease risk, suggesting that gene-gene interaction plays an important role in T2DM susceptibility. 30900957 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease BEFREE In vivo, the BE at the dose of 600 mg/kg was intragastrically given to T2DM mice, which exhibited a certain extent of repair and improvement of the levels of CAT, GSH, GSH-P<sub>X</sub> , SOD, as well as plasma biomarkers, compared with those in the model group (p<0.05). 31609067 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE The CAT haplotype in SOCS3 was associated with metabolic syndrome (MetS) in MEZs, and correlated with protection against high blood pressure (HBP) and risk for high waist circumference and T2D in MAs. 30176313 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE This study showed that daily supplementation with 100 mg of CoQ<sub>10</sub> could increase TAC and CAT activity as, CoQ<sub>10</sub> and QUICKI and could reduce oxidative stress and FBS in women with T2DM. 30505329 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.400 AlteredExpression disease BEFREE Total and mitochondrial ROS production was enhanced in MAO and MADO patients, and mitochondrial membrane potential and catalase activity differed significantly between the MADO and MHO groups. 28630460 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Genetic polymorphisms (Pro197Leu of Gpx1, +35A/C of SOD1, -262C/T of CAT), the level of antioxidant proteins (GPx1, SOD1, CAT) and the risk of distal symmetric polyneuropathy in Polish patients with type 2 diabetes mellitus. 26674569 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We analyzed the association between Cu/Zn-SOD +35 A/C, Mn-SOD T47C, and CAT -21 A/T gene polymorphisms and complications, in combination with tea consumption in Tunisian T2D. 26345792 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Association of the -262C/T polymorphism in the catalase gene promoter and the C242T polymorphism of the NADPH oxidase P22phox gene with essential arterial hypertension in patients with diabetes mellitus type 2. 23701472 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE A significant decrease of SOD (P < 0.05), GPX (P < 0.05) and nonsignificant decrease of CAT (P > 0.05), and TAS status (P > 0.05) were seen in T2DM patients with neuropathy compared to T2DM patients as well as controls. 22718504 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Genetic variants C1167T of CAT gene and +35 A/C of SOD1 gene has no role in insulin resistance in T2DM. 22970972 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE The common MnSOD, GPX1, and CAT TT+CC+CC genotype may contribute to hypertriglyceridemia in Chinese patients with type 2 diabetes or diabetic CVD. 22167619 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Patients were genotyped for ROS-scavenging enzymes, Glutathione peroxidase-1 (GPx-1), Catalase, Mn-SOD, Cu/Zn-SOD, as well as SNPs of NADPH oxidase as ROS-promoting elements, genes related to onset of T2D (CAPN10, ADRB3, PPAR gamma, FATP4). 17825092 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE In this study, we investigated whether the functional -262C/T polymorphism in the promoter of catalase gene is associated with the presence of diabetic retinopathy (DR), diabetic nephropathy (DN) and ischemic heart disease (IHD) in 520 Caucasian-Brazilians with type 2 diabetes. 17264407 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Exon 2 and neighboring introns of the catalase gene may be minor hot spots for type 2 diabetes mellitus susceptibility mutations. 16309371 2005
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Therapeutic disease CTD_human Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. 15531508 2004
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease CTD_human Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. 15111504 2004
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Therapeutic disease CTD_human Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. 15111504 2004
Diabetes Mellitus, Non-Insulin-Dependent
0.400 Biomarker disease CTD_human Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. 15531508 2004
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Lack of association between polymorphisms of catalase, copper-zinc superoxide dismutase (SOD), extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patients with type 2 diabetes mellitus. 11350569 2001
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE We therefore examined the prevalence of the CAC(His) --> CAT(His) mutation in non-diabetic first degree relatives of subjects with type 2 diabetes to determine a possible association of this mutation to leptin levels and insulin sensitivity. 10989952 2000
Diabetes Mellitus, Non-Insulin-Dependent
0.400 GeneticVariation disease BEFREE Members of three families with maturity onset diabetes of youth (MODY) and seven with "common" type 2 diabetes were typed for six DNA markers (H-RAS, INS, HBBC, PTH, CALC1, CAT) on the short arm of chromosome 11. 1587533 1992