|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
The obtained data revealed that administration of Mel before MSCs treatment without preconditioning yielded a better ameliorative effect against DEN-induced hepatocellular carcinoma (HCC) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione S-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes Bax and caspase 3 and downregulated expression of anti-apoptotic genes Bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa B, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene.
|
30925457 |
2019 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Administration of camel milk (orally) and its exosomes (orally and by local injection) decreased breast tumor progression as evident by ( a) higher apoptosis (indicated by higher DNA fragmentation, caspase-3 activity, Bax gene expression, and lower Bcl2 gene expression), ( b) remarkable inhibition of oxidative stress (decrease in MDA levels and iNOS gene expression); ( c) induction of antioxidant status (increased activities of SOD, CAT, and GPX), ( d) notable reduction in expression of inflammation-( IL1b, NFκB), angiogenesis-( VEGF) and metastasis-( MMP9, ICAM1) related genes; and ( e) higher immune response (high number of CD<sup>+</sup>4, CD<sup>+</sup>8, NK1.1 T cells in spleen).
|
29986606 |
2018 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis.
|
27206672 |
2016 |
|
Neoplasm Metastasis
|
0.390 |
Biomarker
|
phenotype |
BEFREE |
Consequently, the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis.
|
25866291 |
2015 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, a decrease in catalase activity or accumulation of hydrogen peroxide correlates with cancer metastasis.
|
24583396 |
2014 |
|
Neoplasm Metastasis
|
0.390 |
Therapeutic
|
phenotype |
CTD_human |
Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells.
|
23518002 |
2013 |
|
Neoplasm Metastasis
|
0.390 |
GeneticVariation
|
phenotype |
BEFREE |
The TT genotype in the CAT C-262T gene polymorphism may also be a risk factor in tumour progression and metastasis among Turkish men.
|
23773345 |
2013 |
|
Neoplasm Metastasis
|
0.390 |
Therapeutic
|
phenotype |
CTD_human |
Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.
|
22580338 |
2012 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
More specifically, alleviation of mitochondrial oxidative stress, via transgenic over-expression of catalase (an anti-oxidant enzyme) targeted to mitochondria, was sufficient to lower tumor grade (from high-to-low) and to dramatically reduce metastatic tumor burden by >12-fold.
|
21605374 |
2011 |
|
Neoplasm Metastasis
|
0.390 |
Therapeutic
|
phenotype |
CTD_human |
Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis.
|
12538496 |
2003 |
|
Neoplasm Metastasis
|
0.390 |
GeneticVariation
|
phenotype |
BEFREE |
Four of six cases that were inoperable due to massive metastasis or invasion had the mutation at codon 273 (CGT to CAT) in exon 8.
|
9554525 |
1998 |
|
Neoplasm Metastasis
|
0.390 |
AlteredExpression
|
phenotype |
BEFREE |
Response was assessed by CAT scan (WHO criteria). p53 protein overexpression was determined immunohistochemically from paraffin sections of the original primary tumour and resected metastases.
|
8608838 |
1996 |