CAT, catalase, 847

N. diseases: 794; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.350 AlteredExpression group BEFREE Administration of camel milk (orally) and its exosomes (orally and by local injection) decreased breast tumor progression as evident by ( a) higher apoptosis (indicated by higher DNA fragmentation, caspase-3 activity, Bax gene expression, and lower Bcl2 gene expression), ( b) remarkable inhibition of oxidative stress (decrease in MDA levels and iNOS gene expression); ( c) induction of antioxidant status (increased activities of SOD, CAT, and GPX), ( d) notable reduction in expression of inflammation-( IL1b, NFκB), angiogenesis-( VEGF) and metastasis-( MMP9, ICAM1) related genes; and ( e) higher immune response (high number of CD<sup>+</sup>4, CD<sup>+</sup>8, NK1.1 T cells in spleen). 29986606 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.350 Biomarker group CTD_human Expression of reactive oxygen species-related proteins according to androgen and HER-2 status in estrogen receptor-negative breast cancer. 25322848 2014
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.350 AlteredExpression group BEFREE This was evident from inhibition of estrogen-induced breast tumor formation in the xenograft model by both overexpression of catalase as well as by co-treatment with Ebselen. 23437041 2013
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.350 GeneticVariation group LHGDN Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk. 18483329 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.350 GeneticVariation group LHGDN Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use. 16192345 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.350 Biomarker group BEFREE These protective effects of FR on survival and tumor incidence were paralleled by higher expression of the tumor suppressor gene p53 (wild type) and free-radical scavenging enzymes (catalase and superoxide dismutase) in breast tumors. 7604020 1995