CNDP1, carnosine dipeptidase 1, 84735

N. diseases: 49; N. variants: 4
Disease: Diabetes Mellitus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 Biomarker group BEFREE These results show for the first time that CN-1 can be detected in urine and warrants prospective studies to assess the relevance of CNU for renal function deterioration in diabetes patients. 29961141 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 Biomarker group BEFREE Cysteine-compounds influence the dynamic behaviour of CN1 and therefore present a promising option for the treatment of diabetes. 28776438 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 GeneticVariation group BEFREE Additionally, it assessed if the prevalence of the protective genotype changes with diabetes duration and time on hemodialysis and if this occurs in association with serum carnosinase (CN-1) activity. 28553654 2017
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 Biomarker group BEFREE We therefore analysed the in vitro and in vivo regulation of CN1 activity using recombinant and human CN1, and the db/db mouse model of diabetes. 26081982 2015
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 GeneticVariation group BEFREE Subjects with DM lacking nephropathy were significantly more likely to be homozygous for the 5-leucine repeat CNDP1 genotype (5-5), compared with those with DN-ESRD (P=0.02). 17205963 2007