Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Although CN-1 is expressed in the kidney, urinary CN-1 (CNU) excretion and its pathological relevance in patients with T2D have not been investigated to date. 29961141 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Our data warrant further studies using large cohorts to confirm these findings and to delineate the correlation between low serum CNDP1 concentrations and renal function deterioration in patients with T2D. 30610469 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE A CNDP1 polymorphism associated with low CN1 activity correlates with significantly reduced risk for diabetic nephropathy, especially in women with type 2 diabetes, and may slow progression of chronic kidney disease in children with glomerulonephritis. 29027595 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression disease BEFREE In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy. 28776438 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Sex specific association between carnosinase gene CNDP1 and cardiovascular mortality in patients with type 2 diabetes (ZODIAC-22). 24756973 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE Rs12604675-A in CNDP1 may confer susceptibility to overt proteinuria in Japanese women with type 2 diabetes. 23342076 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE These data suggest that common variants in CNDP1 and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes. 21573905 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE Additional variants were detected in subgroup analyses: ELMO1 (Asians), CCR5 (Asians) and CNDP1 (type 2 diabetes). 21127830 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker disease BEFREE This study suggests that the association between the CNDP1 gene and diabetic nephropathy is sex specific and independent of susceptibility for type 2 diabetes. 20332346 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation disease BEFREE Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. 20711718 2010