HAT1, histone acetyltransferase 1, 8520

N. diseases: 42; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.300 GeneticVariation disease UNIPROT
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental
0.200 Biomarker phenotype RGD Methyl deficiency, alterations in global histone modifications, and carcinogenesis. 17182829 2007
CUI: C0021704
Disease: Intelligence
Intelligence
0.100 GeneticVariation phenotype GWASCAT Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 31374203 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 GeneticVariation disease GWASCAT Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 31374203 2019
CUI: C0596887
Disease: mathematical ability
mathematical ability
0.100 GeneticVariation phenotype GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 Biomarker group BEFREE The recognition of HAT1 in regulating tumor cell proliferation and cancer immunity indicated that HAT1 might be employed as a new diagnostic and prognostic marker and a predictive marker for pancreatic cancer therapy, especially in immune checkpoint blockade therapy. 30709380 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE Moreover, the in vivo experiment revealed that miR-377 overexpression or HAT1 silencing inhibited tumor growth and reduced tumor size in nude mice. 31152456 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE Furthermore, we found that HAT1 expression was directly correlated with the poor tumor differentiation of EC tissue, which suggested that HAT1 played an important role in esophageal carcinoma and that it could be a novel EC therapeutic target. 25120766 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.020 Biomarker group BEFREE The recognition of HAT1 in regulating tumor cell proliferation and cancer immunity indicated that HAT1 might be employed as a new diagnostic and prognostic marker and a predictive marker for pancreatic cancer therapy, especially in immune checkpoint blockade therapy. 30709380 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.020 Biomarker disease BEFREE The purpose of our investigation was to evaluate the functional relevance of miR-377 in OS and to investigate whether the mechanism was related to the histone acetyltransferase 1 (HAT1)-mediated Wnt signaling pathway. 31152456 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.020 AlteredExpression disease BEFREE Ras-ERK1/2 signalling promotes the development of osteosarcoma through regulation of H4K12ac through HAT1. 30942624 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 AlteredExpression disease BEFREE Ras-ERK1/2 signalling promotes the development of osteosarcoma through regulation of H4K12ac through HAT1. 30942624 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.020 Biomarker disease BEFREE The purpose of our investigation was to evaluate the functional relevance of miR-377 in OS and to investigate whether the mechanism was related to the histone acetyltransferase 1 (HAT1)-mediated Wnt signaling pathway. 31152456 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker group BEFREE The recognition of HAT1 in regulating tumor cell proliferation and cancer immunity indicated that HAT1 might be employed as a new diagnostic and prognostic marker and a predictive marker for pancreatic cancer therapy, especially in immune checkpoint blockade therapy. 30709380 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.020 AlteredExpression disease BEFREE Ras-ERK1/2 signalling promotes the development of osteosarcoma through regulation of H4K12ac through HAT1. 30942624 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.020 Biomarker disease BEFREE The purpose of our investigation was to evaluate the functional relevance of miR-377 in OS and to investigate whether the mechanism was related to the histone acetyltransferase 1 (HAT1)-mediated Wnt signaling pathway. 31152456 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.020 Biomarker group BEFREE RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer. 29535128 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker group BEFREE RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer. 29535128 2018
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.010 Biomarker disease BEFREE These results suggest that HAT1 reduces psoriasis disease activity in a clinically relevant manner. 31419323 2020
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.010 Biomarker disease BEFREE The aim of this study was to investigate the expression pattern of key histone acetyltransferase subtypes (p300, HAT1) in human atherosclerosis and to determine their role in mediating the upregulation of Nox5 in macrophages under inflammatory conditions. 31565149 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.010 Biomarker disease BEFREE The aim of this study was to investigate the expression pattern of key histone acetyltransferase subtypes (p300, HAT1) in human atherosclerosis and to determine their role in mediating the upregulation of Nox5 in macrophages under inflammatory conditions. 31565149 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.010 AlteredExpression disease BEFREE The increased expression of KAT1 and KAT3 mRNA characterized the entire cohorts of patients with UC and CD, as well as relapse-remission subsets. 31666808 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.010 AlteredExpression disease BEFREE The increased expression of KAT1 and KAT3 mRNA characterized the entire cohorts of patients with UC and CD, as well as relapse-remission subsets. 31666808 2019
CUI: C0020473
Disease: Hyperlipidemia
Hyperlipidemia
0.010 Biomarker disease BEFREE These results indicate that swertiamarin exerts lipid-lowering effects through kat-1 regulation and could serve as a possible therapeutic option to improve hyperlipidemia induced comorbidities. 30784937 2019
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.010 AlteredExpression group BEFREE The expression of lymphocytic mRNA encoding enzymes synthesizing KYNA (KAT I-III) and serum levels of TRP and its metabolites were evaluated in 55 patients with IBD, during remission or relapse [27 patients with ulcerative colitis (UC) and 28 patients with Crohn's disease (CD)] and in 50 control individuals. 31666808 2019