Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 Biomarker disease BEFREE CLAC was originally identified in amyloid preparations from AD brain and has been shown to be associated with amyloid plaques, inhibition of Abeta-fibril elongation and increased protease resistance of Abeta-fibrils through direct binding to Abeta. 18501477 2010
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 Biomarker disease BEFREE Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site. 15522881 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 Biomarker disease BEFREE Therefore, we conclude that the AMY immunoreactivity seen in association with amyloid in AD brain is due to the presence of the CLAC protein. 14656069 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 Biomarker disease BEFREE The extracellular domain of CLAC-P/collagen type XXV was secreted by furin convertase, and the N-terminus of CLAC deposited in AD brains was pyroglutamate modified. 11927537 2002