Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338831
Disease: Manic
Manic
0.320 Biomarker disease BEFREE Shank3, a postsynaptic scaffolding protein involved in regulating excitatory synapse assembly and function, has been implicated in several brain disorders, including autism spectrum disorders (ASD), Phelan-McDermid syndrome, schizophrenia, intellectual disability, and mania. 31275112 2019
CUI: C0338831
Disease: Manic
Manic
0.320 AlteredExpression disease BEFREE SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. 24153177 2013
CUI: C0338831
Disease: Manic
Manic
0.320 Biomarker disease PSYGENET The mood-stabilizing drug valproate, but not lithium, rescues the manic-like behaviour of Shank3 transgenic mice raising the possibility that this hyperkinetic disorder has a unique pharmacogenetic profile. 24153177 2013