Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Recently, we reported that the herpesvirus entry mediator (HVEM; also called TNFRSF14 or CD270) is upregulated by the latency-associated transcript (LAT) of herpes simplex virus 1 (HSV-1) and that the absence of HVEM affects latency reactivation but not primary infection in ocularly infected mice. gD has been shown to bind to HVEM. 30282707 2018
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE In summary, we found that monoclonal antibodies derived from humans vaccinated with the HVEM binding domain of HSV-1 gD (i) neutralized HSV-1 infection in a cell receptor-specific manner, (ii) mediated ADCC, and (iii) reduced ocular disease in virus-infected mice.<b>IMPORTANCE</b> Herpes simplex virus 1 (HSV-1) causes cold sores and neonatal herpes and is a leading cause of blindness. 28701403 2017
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE To determine cellular and temporal expression patterns of herpes virus entry mediator (HVEM, Tnfrsf14) in the murine cornea during the course of herpes simplex virus 1 (HSV-1) infection, the impact of this expression on pathogenesis, and whether alterations in HVEM or downstream HVEM-mediated effects ameliorate corneal disease. 28114589 2017
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Here, we review the dual branches of HVEM function during HSV infection: entry and immunomodulation. 28404853 2017
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) can both mediate the entry of herpes simplex virus 1 (HSV-1). 26136572 2015
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1. 24314649 2014
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 AlteredExpression group BEFREE HVEM acts as both a receptor for the canonical TNF-related ligands, LIGHT [lymphotoxin-like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed on T lymphocytes] and lymphotoxin-α, and as a ligand for the immunoglobulin superfamily proteins BTLA (B and T lymphocyte attenuator) and CD160, a feature distinguishing HVEM from other immune regulatory molecules. 22017438 2011
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition. 20826693 2010
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Herpes simplex virus (HSV) entry into cells is triggered by the binding of envelope glycoprotein D (gD) to a specific receptor, such as nectin-1 or herpesvirus entry mediator (HVEM), resulting in activation of the fusion effectors gB and gH and virus penetration. 20861246 2010
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group LHGDN Involvement of HVEM receptor in activation of nuclear factor kappaB by herpes simplex virus 1 glycoprotein D. 18671825 2008
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Either herpesvirus entry mediator (HVEM, TNFRSF14) or nectin-1 (PVRL1) is sufficient for herpes simplex virus (HSV) infection of cultured cells. 18005714 2007
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 AlteredExpression group BEFREE In this study, we have shown that adenovirus-expressing TNFSF14 [LIGHT (name derived from homologous to lymphotoxins, shows inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes); Ad-LIGHT] inoculated directly into primary 4T1 tumor, a highly aggressive, spontaneously metastasizing mammary carcinoma, followed by surgical removal of the primary tumor can eradicate established and disseminated metastatic tumor cells in the peripheral tissues. 17641063 2007
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE CIN85 also suppressed HSV-1 growth in Chinese hamster ovary (CHO) cells expressing the receptor for herpes simplex virus entry (herpes virus entry mediator A; HVEM). 16223483 2005
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells. 16189018 2005
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator. 15016549 2004
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE The relative usage of HVEM and nectin-1 during HSV infection in vivo is not known. 15110526 2004
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group LHGDN Herpes simplex virus (HSV) entry requires the interaction of glycoprotein D (gD) with a cellular receptor such as herpesvirus entry mediator (HVEM or HveA) or nectin-1 (HveC). 12915568 2003
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group LHGDN Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA. 11976496 2002