Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, we reported that the herpesvirus entry mediator (HVEM; also called TNFRSF14 or CD270) is upregulated by the latency-associated transcript (LAT) of herpes simplex virus 1 (HSV-1) and that the absence of HVEM affects latency reactivation but not primary infection in ocularly infected mice. gD has been shown to bind to HVEM.
|
30282707 |
2018 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, we found that monoclonal antibodies derived from humans vaccinated with the HVEM binding domain of HSV-1 gD (i) neutralized HSV-1 infection in a cell receptor-specific manner, (ii) mediated ADCC, and (iii) reduced ocular disease in virus-infected mice.<b>IMPORTANCE</b> Herpes simplex virus 1 (HSV-1) causes cold sores and neonatal herpes and is a leading cause of blindness.
|
28701403 |
2017 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine cellular and temporal expression patterns of herpes virus entry mediator (HVEM, Tnfrsf14) in the murine cornea during the course of herpes simplex virus 1 (HSV-1) infection, the impact of this expression on pathogenesis, and whether alterations in HVEM or downstream HVEM-mediated effects ameliorate corneal disease.
|
28114589 |
2017 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we review the dual branches of HVEM function during HSV infection: entry and immunomodulation.
|
28404853 |
2017 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) can both mediate the entry of herpes simplex virus 1 (HSV-1).
|
26136572 |
2015 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1.
|
24314649 |
2014 |
Herpes Simplex Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HVEM acts as both a receptor for the canonical TNF-related ligands, LIGHT [lymphotoxin-like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed on T lymphocytes] and lymphotoxin-α, and as a ligand for the immunoglobulin superfamily proteins BTLA (B and T lymphocyte attenuator) and CD160, a feature distinguishing HVEM from other immune regulatory molecules.
|
22017438 |
2011 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition.
|
20826693 |
2010 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus (HSV) entry into cells is triggered by the binding of envelope glycoprotein D (gD) to a specific receptor, such as nectin-1 or herpesvirus entry mediator (HVEM), resulting in activation of the fusion effectors gB and gH and virus penetration.
|
20861246 |
2010 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Involvement of HVEM receptor in activation of nuclear factor kappaB by herpes simplex virus 1 glycoprotein D.
|
18671825 |
2008 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Either herpesvirus entry mediator (HVEM, TNFRSF14) or nectin-1 (PVRL1) is sufficient for herpes simplex virus (HSV) infection of cultured cells.
|
18005714 |
2007 |
Herpes Simplex Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we have shown that adenovirus-expressing TNFSF14 [LIGHT (name derived from homologous to lymphotoxins, shows inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes); Ad-LIGHT] inoculated directly into primary 4T1 tumor, a highly aggressive, spontaneously metastasizing mammary carcinoma, followed by surgical removal of the primary tumor can eradicate established and disseminated metastatic tumor cells in the peripheral tissues.
|
17641063 |
2007 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
CIN85 also suppressed HSV-1 growth in Chinese hamster ovary (CHO) cells expressing the receptor for herpes simplex virus entry (herpes virus entry mediator A; HVEM).
|
16223483 |
2005 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells.
|
16189018 |
2005 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator.
|
15016549 |
2004 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The relative usage of HVEM and nectin-1 during HSV infection in vivo is not known.
|
15110526 |
2004 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Herpes simplex virus (HSV) entry requires the interaction of glycoprotein D (gD) with a cellular receptor such as herpesvirus entry mediator (HVEM or HveA) or nectin-1 (HveC).
|
12915568 |
2003 |
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA.
|
11976496 |
2002 |