|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Lymphocyte Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
|
22286170 |
2012 |
|
Huntington Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
This makes P42 peptide potentially suitable not only to prevent, but also to treat HD.
|
29860423 |
2018 |
|
Huntington Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
The P42 peptide and Peptide-based therapies for Huntington's disease.
|
26984770 |
2016 |
|
Huntington Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
These data also demonstrate a specific role of P42 on Huntington's disease model, since it has no effect on other models of polyQ-induced diseases, such as spinocerebellar ataxias.
|
23861941 |
2013 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
DSCAM-AS1 was significantly up-regulated in CRC samples, and its expression was positively correlated with the expression of CDKL1 and negatively correlated with the expression of miR-144-5p.
|
31730864 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that CDKL1 plays an important role in NB cell proliferation, migration and invasion.
|
30891073 |
2019 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
CDKL1 is a member of the cell division cycle 2 (CDC2)-related serine threonine protein kinase family and is overexpressed in malignant tumors such as melanoma, breast cancer, and gastric cancer.
|
28352193 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To investigate the role of CDKL1 in colorectal cancer, CDKL1-small hairpin RNA-expressing lentivirus was constructed and infected into HCT116 and Caco2 cells.
|
28352193 |
2017 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CDKL1 is a member of the cell division cycle 2 (CDC2)-related serine threonine protein kinase family and is overexpressed in malignant tumors such as melanoma, breast cancer, and gastric cancer.
|
28352193 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The effects of RNA interference (RNAi)-mediated CDKL1 downregulation on cell proliferation and invasion were assessed by CCK-8, colony formation, transwell, and tumorigenicity assays in nude mice.
|
28352193 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Cyclin-dependent kinase-like 1 (CDKL1) is a member of cell division control protein 2 (CDC-2)-related serine threonine protein kinase family, and is reported to be overexpressed in malignant tumors such as breast cancer and gastric cancer.
|
25920913 |
2015 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CDKL1 is associated with melanoma cell growth, colony formation, apoptosis, and cell cycle regulation.
|
25920913 |
2015 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that CDKL1 plays an important role in NB cell proliferation, migration and invasion.
|
30891073 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that CDKL1 plays an important role in NB cell proliferation, migration and invasion.
|
30891073 |
2019 |
|
Brain Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Delayed intraventricular transplantation of 1 × 10<sup>5</sup> thrombin preconditioned but not naïve MSCs at 24 h after hypothermia significantly enhanced observed anti-inflammatory, anti-astroglial, and anti-apoptotic effects and the ensuing brain infarction; behavioral tests, such as cylinder rearing and negative geotaxis tests, were conducted at P42.
|
31137455 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
YC-1 Antagonizes Wnt/β-Catenin Signaling Through the EBP1 p42 Isoform in Hepatocellular Carcinoma.
|
31086087 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that CDKL1 plays an important role in NB cell proliferation, migration and invasion.
|
30891073 |
2019 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
CDKL1 plays a vital role in tumor proliferation and invasion in colorectal cancer in vitro and in vivo and, thus, may be considered as a valuable target for therapeutic intervention.
|
28352193 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the role of CDKL1 in colorectal cancer, CDKL1-small hairpin RNA-expressing lentivirus was constructed and infected into HCT116 and Caco2 cells.
|
28352193 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, our data show that excess p30 cooperated with TRIB2 only in the presence of p42 to accelerate AML, and the direct interaction and degradation of C/EBPα p42 is required for TRIB2-mediated AML.
|
26996668 |
2016 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin-dependent kinase-like 1 (CDKL1) is a member of cell division control protein 2 (CDC-2)-related serine threonine protein kinase family, and is reported to be overexpressed in malignant tumors such as breast cancer and gastric cancer.
|
25920913 |
2015 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We studied EBP1, an ErbB3 binding protein, and the effects of p48 and p42 isoforms on the MHC II expression in U87 glioblastoma, M14 melanoma and MCF7 mammary carcinoma cell lines.
|
26081906 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Restoring C/EBPα P42 is an attractive approach for differentiation therapy in ATRA resistant APL.
|
26397153 |
2015 |