Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.350 Biomarker disease BEFREE PXR has been shown to play a critical role in metabolic changes in obesity and diabetes; however, its distribution and function in the kidney are unknown. 29212764 2018
CUI: C0028754
Disease: Obesity
Obesity
0.350 Biomarker disease BEFREE Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression. 28756207 2017
CUI: C0028754
Disease: Obesity
Obesity
0.350 Biomarker disease BEFREE Recent studies have revealed novel and unexpected roles of PXR in modulating obesity, insulin sensitivity, lipid homeostasis, atherogenesis, and vascular functions. 26924429 2016
CUI: C0028754
Disease: Obesity
Obesity
0.350 Biomarker disease BEFREE Importantly, although HFD-fed hPXR mice were resistant to HFD-induced obesity, both PXR-KO and hPXR mice exhibited impaired induction of glucokinase involved in glucose utilization and displayed elevated fasting glucose levels and severely impaired glucose tolerance. 24362030 2014
CUI: C0028754
Disease: Obesity
Obesity
0.350 Biomarker disease BEFREE Together, these studies indicate that the hPXR gene promotes obesity and metabolic syndrome by dysregulating lipid and glucose homeostasis while inhibiting UCP1 expression. 24721462 2014
CUI: C0028754
Disease: Obesity
Obesity
0.350 Biomarker disease CTD_human CAR and PXR are involved in the development of certain diseases, including diabetes, metabolic syndrome and obesity. 20869355 2010