Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.330 Biomarker disease BEFREE PXR has, additionally, a multifactorial impact on cancer, either by directly affecting cell proliferation and apoptosis or by inducing chemotherapy resistance, in colon, breast, prostate, and endometrial cancer, and in osteosarcoma. 23413096 2013
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.330 AlteredExpression disease BEFREE We silenced the expression of the main PAR-synthesizing enzyme PARP-1 and the PAR-degrading enzyme poly(ADP-ribose) glycohydrolase (PARG) in SAOS-2 osteosarcoma cells (shPARP-1 and shPARG, respectively). 22940495 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.330 Biomarker disease CTD_human Cytotoxicity assays showed that the resistance of the osteosarcoma cell lines to etoposide correlated with PXR protein expression levels and activation of P450 3A4 and could be prevented by ketoconazole. 17279585 2007
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.330 AlteredExpression disease BEFREE Cytotoxicity assays showed that the resistance of the osteosarcoma cell lines to etoposide correlated with PXR protein expression levels and activation of P450 3A4 and could be prevented by ketoconazole. 17279585 2007
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.330 AlteredExpression disease LHGDN Cytotoxicity assays showed that the resistance of the osteosarcoma cell lines to etoposide correlated with PXR protein expression levels and activation of P450 3A4 and could be prevented by ketoconazole. 17279585 2007