WNT3A, Wnt family member 3A, 89780

N. diseases: 141; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.020 AlteredExpression disease BEFREE In addition, we show that Wnt3a-induced OPG expression was diminished in osteoblasts cocultured with a DKK1-expressing MM cell line or primary MM cells. 18305214 2008
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.020 Biomarker disease LHGDN Likewise, treatment of myelomatous SCID-hu mice, carrying primary disease, with recombinant Wnt3a stimulated bone formation and attenuated MM growth. 18344425 2008
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.020 AlteredExpression disease LHGDN Finally, we show that bone marrow sera from 21 MM patients significantly suppressed Wnt3a-induced OPG expression and enhanced RANKL expression in osteoblasts in a DKK1-dependent manner. 18305214 2008