|
Breast Carcinoma
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
We observed effect modification of current MHT use on overall BC risk by two SNPs on chr13 near POMP (combined Pint≤8.9 × 10(-6)), two SNPs in SLC25A21 (combined Pint≤4.8 × 10(-5)), and three SNPs in PLCG2 (combined Pint≤4.5 × 10(-5)).
|
24080446 |
2013 |
|
Breast Carcinoma
|
0.120 |
AlteredExpression
|
disease |
BEFREE |
ODC was overexpressed in breast cancer tissues and cell lines compared with non-tumor tissues and normal breast epithelial cells, and there was a positive correlation between the level of ODC mRNA and the staging of tumors.
|
18330478 |
2008 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cleft upper lip
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.
|
28232668 |
2017 |
|
Cleft Palate
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.
|
28232668 |
2017 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum LDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
ODC and polyamine levels are often up-regulated and contribute to tumor hyperproliferation, especially of MYC-driven cancers.
|
30404920 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
RT-PCR, Western blotting, MTT, and tumor growth inhibition assay in nude mice demonstrated that pADxsi-P1-AdoMetDC-ODC-PolyA and pADxsi-P2-AdoMetDC-ODC-PolyA exhibited inhibitory effects on cell proliferation at both the gene and protein levels.
|
19517275 |
2010 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
ODC was overexpressed in breast cancer tissues and cell lines compared with non-tumor tissues and normal breast epithelial cells, and there was a positive correlation between the level of ODC mRNA and the staging of tumors.
|
18330478 |
2008 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
ODC mRNA (messenger ribonucleic acid), ODC activity, number of mitoses, and Ki-67 index as a marker for nuclear proliferation were quantified in three different groups of meningiomas: tumors without recurrence in a 8.4 years median follow-up period, tumors with recurrence within a median follow-up of 3.0 years, and their corresponding recurrent tumors.
|
11678434 |
2001 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
ODC mRNA was elevated 5-fold in MDA-MB-231 cells versus MCF-7 cells when analyzed in cell culture.
|
8519686 |
1995 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
About 47% and 16% of these tumor samples also showed increased levels of ODC (mean 3.1-fold) and beta-actin (mean 1.6-fold) RNA, respectively.
|
1693276 |
1990 |
|
Neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
To this end, the MYC-ODC axis presents an attractive target for managing cancers such as neuroblastoma, a pediatric malignancy in which <i>MYCN</i> gene amplification correlates with poor prognosis and high-risk disease.
|
30404920 |
2018 |
|
Central neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
To this end, the MYC-ODC axis presents an attractive target for managing cancers such as neuroblastoma, a pediatric malignancy in which <i>MYCN</i> gene amplification correlates with poor prognosis and high-risk disease.
|
30404920 |
2018 |
|
Childhood Neuroblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
To this end, the MYC-ODC axis presents an attractive target for managing cancers such as neuroblastoma, a pediatric malignancy in which <i>MYCN</i> gene amplification correlates with poor prognosis and high-risk disease.
|
30404920 |
2018 |
|
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded NB cell proliferation.
|
26093909 |
2015 |
|
Central neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded NB cell proliferation.
|
26093909 |
2015 |
|
Childhood Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded NB cell proliferation.
|
26093909 |
2015 |
|
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ODC mRNA expression in NB tumors was significantly predictive of decreased overall survival probability and correlated with several unfavorable clinical NB characteristics (all p < 0.005).
|
19960435 |
2010 |
|
Central neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ODC mRNA expression in NB tumors was significantly predictive of decreased overall survival probability and correlated with several unfavorable clinical NB characteristics (all p < 0.005).
|
19960435 |
2010 |
|
Childhood Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ODC mRNA expression in NB tumors was significantly predictive of decreased overall survival probability and correlated with several unfavorable clinical NB characteristics (all p < 0.005).
|
19960435 |
2010 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
These mRNAs encode proteins that play significant roles in all aspects of malignancy including angiogenesis factors (VEGF, FGF-2), onco-proteins (c-myc, cyclin D1, ODC), pro-survival proteins (survivin, BCL-2) and proteins involved in tumor invasion and metastasis (MMP-9, heparanase).
|
18719377 |
2008 |