Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Growth Hormone-Secreting Pituitary Adenoma
0.390 GeneticVariation disease BEFREE Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas. 29729370 2018
Growth Hormone-Secreting Pituitary Adenoma
0.390 Biomarker disease BEFREE Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas. 27998919 2017
Growth Hormone-Secreting Pituitary Adenoma
0.390 AlteredExpression disease BEFREE In this review, we summarise the most recent studies on AIP-related pituitary adenomas, paying special attention to the causes of somatostatin resistance; the somatostatin receptor profile including type 2, type 5 and truncated variants; the role of G proteins in this pathology; the use of first and second generation somatostatin analogues; and the role of ZAC1, a zinc-finger protein with expression linked to AIP in somatotrophinoma models and acting as a key mediator of octreotide response. 28835453 2017
Growth Hormone-Secreting Pituitary Adenoma
0.390 GeneticVariation disease BEFREE These results suggest that Q228K and Q307R variants in the AIP gene might be involved in the genetic susceptibility to familial and sporadic pituitary adenomas (somatotrophinoma and corticotrophinoma) in the Turkish population. 25938168 2015
Growth Hormone-Secreting Pituitary Adenoma
0.390 GeneticVariation disease BEFREE This study implies for the first time that a failure to inhibit cAMP synthesis through dysfunctional Gαi signaling underlies the development of GH-secreting pituitary adenomas in AIP mutation carriers. 24662816 2015
Growth Hormone-Secreting Pituitary Adenoma
0.390 GeneticVariation disease BEFREE Familial and sporadic GH-secreting pituitary adenomas are associated with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene. 25093619 2014
Growth Hormone-Secreting Pituitary Adenoma
0.390 GeneticVariation disease BEFREE No AIP mutation was found neither in growth hormone-secreting pituitary adenoma patients, nor in the unrelated patients without pituitary adenoma. 22915287 2013
Growth Hormone-Secreting Pituitary Adenoma
0.390 GeneticVariation disease BEFREE AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. 23674160 2013
Growth Hormone-Secreting Pituitary Adenoma
0.390 GeneticVariation disease BEFREE We examined the frequency of AIP mutations in pituitary tumors and blood of Canadian patients with sporadic pituitary somatotroph adenomas and sporadic pituitary adenomas of other types. 17916996 2007
Growth Hormone-Secreting Pituitary Adenoma
0.390 Biomarker disease CTD_human