Obstruction of pelviureteric junction
|
0.700 |
GeneticVariation
|
phenotype |
UNIPROT |
Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.
|
26235987 |
2015 |
Obstruction of pelviureteric junction
|
0.700 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.
|
26235987 |
2015 |
Obstruction of pelviureteric junction
|
0.700 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
|
|
|
Obstruction of pelviureteric junction
|
0.700 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
Obstruction of pelviureteric junction
|
0.700 |
Biomarker
|
phenotype |
HPO |
|
|
|
MULTICYSTIC RENAL DYSPLASIA, BILATERAL
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
MULTICYSTIC RENAL DYSPLASIA, BILATERAL
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Hydronephrosis Due To Pujo
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.
|
30575882 |
2018 |
Flank Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Hydronephrosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Nephrotic Syndrome
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
Renal Cell Dysplasia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Congenital hypoplasia of kidney
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Congenital dilatation of ureter
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Sarcoma of kidney
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Dilatation of ureter
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Cystic renal dysplasia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Renal dysplasia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Multicystic Dysplastic Kidney
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Complete atrioventricular block
|
0.040 |
Biomarker
|
disease |
BEFREE |
Following a previous in vitro study reporting the production of Tbx18-expressing human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), we aimed to investigate the efficacy of these engineered cells to generate pacemaker rhythms in a murine model of complete heart block.
|
30677516 |
2019 |
Complete atrioventricular block
|
0.040 |
Biomarker
|
disease |
BEFREE |
In protocol B, full-blown RV PICM was evident 4 weeks after complete AV block in both groups; subsequent intervention led to higher mean heart rate (56 ± 2 beats/min vs. 50.1 ± 0.4 beats/min; p = 0.05), less backup pacemaker utilization (53 ± 8.2% vs. 95 ± 1.6%; p = 0.003), and a greater ejection fraction (61.7 ± 1.3% vs. 49 ± 1.6%; p = 0.0003) in TBX18-injected animals versus control animals.
|
30947921 |
2019 |
Complete atrioventricular block
|
0.040 |
Biomarker
|
disease |
BEFREE |
Focal somatic gene transfer of TBX18 to the left ventricular apex in the CAVB rats resulted in ectopic ventricular beats within days, achieving a de novo ventricular rate faster than the slow atrioventricular (AV) junctional escape rhythm observed in control CAVB animals.
|
31061413 |
2019 |