Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data indicate an essential and systemic role for TG2 in bridging inflammation to hypertension via its posttranslational modifications stabilizing AT1 receptor and sensitizing Ang II.
|
30715101 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension.
|
30842613 |
2019 |
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although exogenous angiotensin II (AngII) can increase NMDAR activity in the PVN, whether endogenous AT1 receptor-protein kinase C (PKC) activity mediates the augmented NMDAR activity of PVN presympathetic neurons in hypertension is unclear.
|
31241170 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Findings support that FPH is associated with a vascular hyper-sympathetic activation, involving a tonic facilitation of prejunctional AT1 receptors by endogenous Ang II, which can justify, at least in part, the development of hypertension.
|
30326265 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, our data show that spinal ionotropic glutamatergic and AT1 receptors contribute to increased rSNA in the 2K1C model, leading to the maintenance of hypertension; however, the participation of spinal AT1 receptors seems to be especially important in the establishment of sympathoexcitation in this model.
|
29935157 |
2018 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present work, we explored the changes in the expression of angiotensin II receptor, type 1 (AT<sub>1</sub> receptor) in limbic structures, as well as the effect of the AT1 receptor antagonist losartan in a model of comorbid hypertension and epilepsy.
|
29223539 |
2018 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The AT1 receptor promotes various intracellular signaling pathways resulting in hypertension, endothelial dysfunction, vascular remodeling and end organ damage.
|
28527699 |
2017 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that enhanced constrictive responsiveness of renal afferent arterioles (Af-Art) to angiotensin II (ANG II) mediated by ANG II type 1 (AT1) receptors contributes to the development of hypertension in diabetes.
|
28842434 |
2017 |
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
G4+/- offspring on a HFD displayed early hypertension associated with increased renal gene expression of renin and the AT1- receptors compared to G4+/- on a C diet.
|
28750406 |
2017 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Losartan is a selective antagonist of AngⅠ type (AT1) receptor of Angiotensin Ⅱ (Ang Ⅱ), which is widely used as a clinical medicine for the hypertension.
|
28483563 |
2017 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.
|
26787451 |
2016 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension.
|
25990648 |
2015 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the BP response to AT1 receptor blockers varied significantly among individuals with hypertension.
|
24131669 |
2014 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established.
|
24414230 |
2014 |
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The uremic environment seems to dominate over previously reported actions of high blood pressure and cholesterol to enhance leukocyte Angiotensin II AT1 receptor expression.
|
21640098 |
2011 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The present meta-analysis suggests that the AT(1) receptor 1166 AC/CC genotype is associated with susceptibility to hypertension in the Chinese population.
|
20223791 |
2010 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that chronic elevation of Ang IV in the brain can induce hypertension that can be treated with angiotensin II AT1 receptor antagonists.
|
15117826 |
2004 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The A1166C polymorphism of the AT1 receptor gene (AT1R/A1166C) is associated with hypertension in Caucasians, but not in Japanese.
|
15492474 |
2004 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We have investigated whether the A1166C polymorphism of the angiotensin II type 1 (AT1) receptor gene modulates the effects of angiotensin II on collagen type I turnover and myocardial stiffness in hypertension.
|
14597852 |
2003 |
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Therefore, we conducted an association study between A1166C variants of the AT1 receptor gene and hypertension in the Japanese population.
|
12627871 |
2003 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggested that in vivo expression of h-chymase caused mild hypertension (AT1 receptor-dependent) with left ventricular hypertrophy (partially AT1 receptor-dependent), and also chronic inflammatory changes (AT1 receptor-independent).
|
14620933 |
2003 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Candesartan, an AT(1) receptor antagonist, has been reported to have no association with persistent cough in subjects with hypertension, but there has been no study on the safety of its administration to hypertensive patients with symptomatic asthma.
|
11457745 |
2001 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
To address the hypothesis that increased myocardial AT1 receptor density causes cardiac hypertrophy apart from high blood pressure we developed a transgenic rat model which expresses the human AT1 receptor under the control of the alpha-myosin heavy-chain promoter specifically in the myocardium.
|
11692158 |
2001 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Systemic delivery of recombinant adeno-associated virus with DNA antisense to AT(1) receptors in adult rodents decreases hypertension for up to 6 months.
|
11566928 |
2001 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
AS-ODNs, targeted to AT1 receptors (AT1R), angiotensinogen (AGT), angiotensin converting enzyme (ACE) and beta 1-adrenergic receptors effectively reduce hypertension in rat models (SHR, 2K-1C and cold-induced) hypertension.
|
11727501 |
2001 |