Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 AlteredExpression group BEFREE Our data indicate an essential and systemic role for TG2 in bridging inflammation to hypertension via its posttranslational modifications stabilizing AT1 receptor and sensitizing Ang II. 30715101 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension. 30842613 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 AlteredExpression group BEFREE Although exogenous angiotensin II (AngII) can increase NMDAR activity in the PVN, whether endogenous AT1 receptor-protein kinase C (PKC) activity mediates the augmented NMDAR activity of PVN presympathetic neurons in hypertension is unclear. 31241170 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Findings support that FPH is associated with a vascular hyper-sympathetic activation, involving a tonic facilitation of prejunctional AT1 receptors by endogenous Ang II, which can justify, at least in part, the development of hypertension. 30326265 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Thus, our data show that spinal ionotropic glutamatergic and AT1 receptors contribute to increased rSNA in the 2K1C model, leading to the maintenance of hypertension; however, the participation of spinal AT1 receptors seems to be especially important in the establishment of sympathoexcitation in this model. 29935157 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE In the present work, we explored the changes in the expression of angiotensin II receptor, type 1 (AT<sub>1</sub> receptor) in limbic structures, as well as the effect of the AT1 receptor antagonist losartan in a model of comorbid hypertension and epilepsy. 29223539 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE The AT1 receptor promotes various intracellular signaling pathways resulting in hypertension, endothelial dysfunction, vascular remodeling and end organ damage. 28527699 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE We hypothesized that enhanced constrictive responsiveness of renal afferent arterioles (Af-Art) to angiotensin II (ANG II) mediated by ANG II type 1 (AT1) receptors contributes to the development of hypertension in diabetes. 28842434 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 AlteredExpression group BEFREE G4+/- offspring on a HFD displayed early hypertension associated with increased renal gene expression of renin and the AT1- receptors compared to G4+/- on a C diet. 28750406 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Losartan is a selective antagonist of AngⅠ type (AT1) receptor of Angiotensin Ⅱ (Ang Ⅱ), which is widely used as a clinical medicine for the hypertension. 28483563 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension. 26787451 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation group BEFREE Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. 25990648 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Furthermore, the BP response to AT1 receptor blockers varied significantly among individuals with hypertension. 24131669 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. 24414230 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 AlteredExpression group BEFREE The uremic environment seems to dominate over previously reported actions of high blood pressure and cholesterol to enhance leukocyte Angiotensin II AT1 receptor expression. 21640098 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation group BEFREE The present meta-analysis suggests that the AT(1) receptor 1166 AC/CC genotype is associated with susceptibility to hypertension in the Chinese population. 20223791 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE These results suggest that chronic elevation of Ang IV in the brain can induce hypertension that can be treated with angiotensin II AT1 receptor antagonists. 15117826 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation group BEFREE The A1166C polymorphism of the AT1 receptor gene (AT1R/A1166C) is associated with hypertension in Caucasians, but not in Japanese. 15492474 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation group BEFREE We have investigated whether the A1166C polymorphism of the angiotensin II type 1 (AT1) receptor gene modulates the effects of angiotensin II on collagen type I turnover and myocardial stiffness in hypertension. 14597852 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 GeneticVariation group BEFREE Therefore, we conducted an association study between A1166C variants of the AT1 receptor gene and hypertension in the Japanese population. 12627871 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE These data suggested that in vivo expression of h-chymase caused mild hypertension (AT1 receptor-dependent) with left ventricular hypertrophy (partially AT1 receptor-dependent), and also chronic inflammatory changes (AT1 receptor-independent). 14620933 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Candesartan, an AT(1) receptor antagonist, has been reported to have no association with persistent cough in subjects with hypertension, but there has been no study on the safety of its administration to hypertensive patients with symptomatic asthma. 11457745 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE To address the hypothesis that increased myocardial AT1 receptor density causes cardiac hypertrophy apart from high blood pressure we developed a transgenic rat model which expresses the human AT1 receptor under the control of the alpha-myosin heavy-chain promoter specifically in the myocardium. 11692158 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE Systemic delivery of recombinant adeno-associated virus with DNA antisense to AT(1) receptors in adult rodents decreases hypertension for up to 6 months. 11566928 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.100 Biomarker group BEFREE AS-ODNs, targeted to AT1 receptors (AT1R), angiotensinogen (AGT), angiotensin converting enzyme (ACE) and beta 1-adrenergic receptors effectively reduce hypertension in rat models (SHR, 2K-1C and cold-induced) hypertension. 11727501 2001