CD6, CD6 molecule, 923

N. diseases: 216; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE Majority of the patients had<br /> pre-B-cell ALL (88.7%), WBC count <50, 000/μL at diagnosis (76.1%, median = 13.5/μL with a range of 0.51-553.0/<br /> μL) with involvement of central nervous system (CNS) disease in 8.5%patients.Different common chromosomal<br /> anomalies or abnormalities, including t(12, 21) translocation, MLL genre arrangements, trisomy (4, 10, 17)and others,<br /> were detected. 31759364 2019
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE Notably, the t(12;21) translocation leading to an ETV6-AML1 fusion gene is the most common genetic alteration found in childhood acute lymphoblastic leukemia. 30341373 2018
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE Patients with standard-risk ALL, who received the longest maintenance therapy, had the highest adjusted hazard of second cancer (hazard ratio [HR], intermediate vs. standard risk: 0.16, 95% CI: 0.06-0.43, P < 0.001; HR, high vs. standard risk: 0.09, 95% CI: 0.02-0.49, P = 0.006); no significant effects of protocol, age, or white blood cell count at diagnosis, ALL HeH, or t(12;21)[ETV6/RUNX1] were observed. 28500740 2017
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE A search in the literature revealed two additional pediatric patients with cryptic der(6)t(X;6) in t(12;21)-positive ALLs. 27215399 2016
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE Childhood acute lymphoblastic leukemia (ALL) with t(12;21), which results in expression of the ETV6/RUNX1 fusion gene, is the most common chromosomal lesion in precursor-B (pre-B) ALL. 26580398 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene. 25893288 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE TEL-AML1 fusion oncogene (t 12; 21) is the most common chromosomal abnormality in childhood acute lymphoblastic leukemia (ALL). 24870754 2014
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE Sequencing analysis of >1,000 pediatric cancer genomes identified the NSD2 p.E1099K alteration in 14% of t(12;21) ETV6-RUNX1-containing ALLs. 24076604 2013
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE This joint effect was seen for B-cell precursor ALL with t(12;21) (OR = 2.08; 95% CI, 1.04-4.16), but not high hyperdiploid B-cell ALL. 23853208 2013
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE Interrogation of expression databases of 257 ALL samples demonstrated the specific down-regulation of the SPIB and IKZF3 genes (the latter encoding AIOLOS) in t(12;21) ALL, providing novel insight into the mechanism by which the translocation blocks B-cell development and promotes leukemia. 23704093 2013
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE Although the true pathogenetic significance of the mutations must await future functional evaluations, this study provides a first estimate of the mutational burden at the genetic level of t(12;21)-positive childhood ALL. 22094584 2012
Childhood Acute Lymphoblastic Leukemia
0.100 AlteredExpression disease BEFREE In comparison with Western cohorts, the incidence of t(9;22) (q34;q11)/BCR-ABL (14.60%) in B-ALL and HOX11 expression in T-ALL (25.24%) seemed to be much higher in our group, while the incidence of t(12;21) (p13;q22)/ETV6-RUNX1 (15.34%) seemed to be lower in Chinese pediatric patients. 22382891 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE This includes cell lines derived from patients with relapsed disease featuring cytogenetic anomalies such as t(12;21), Philadelphia chromosome t(9;22), t(1;19) as well as a cell line carrying t(17;19) from a patient with de novo ALL. 21960246 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE Genes that were differentially expressed between BCP ALL subtypes were enriched to distinct signaling pathways with dic(9;20) enriched to TP53 signaling, t(9;22) to interferon signaling, as well as high hyperdiploidy and t(12;21) to apoptosis signaling. 22173241 2012
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. 22099053 2012
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE In B-ALL KIBRA methylation was associated with ETV6/RUNX1 [t(12;21) (p13;q22)] chromosomal translocation (p = 0.0082) phenotype, suggesting that KIBRA may play an important role in t(12;21) leukemogenesis. 21173572 2011
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE Detection of early precursors of t(12;21) positive pediatric acute lymphoblastic leukemia during follow-up. 19813247 2010
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE This study revealed that e.g., the t(12;21) [ETV6-RUNX1] subtype of ALL and the t(15;17) [PML-RARA] subtype of AML had transcriptional programs similar to those in normal Pro-B cells and promyelocytes, respectively. 20211010 2010
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation disease BEFREE In this cohort of Taiwanese children, the relative frequencies of the 4 translocations of B-lineage ALL were 8% with ALL-type t(9;22)/BCR-ABL1, 4% with (1;19)/TCF-PBX1, 2% with t(4;11)/MLL-AF4, and 17.6% with t(12;21)/ETV6-RUNX1. 20930648 2010
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE It also stratified patients with high hyperdiploidy and t(12;21) ALL into 2 subgroups with different probability of relapse. 19965625 2010
Childhood Acute Lymphoblastic Leukemia
0.100 AlteredExpression disease BEFREE Folylpolyglutamate synthetase (FPGS) activity was higher in B vs T lineage ALL (p<0.005), MTX influx and FPGS activity were higher in hyperdiploid vs non-hyperdiploid ALL (p<0.03), MTX influx and FPGS activity were lower in the t(12;21) (ETV6-RUNX1) subtype (p<0.05), and the ratio of FPGS to γ-glutamyl hydrolase (GGH) activity was lower in the t(1;19) (TCF3-PBX1) subtype (p<0.03) than other genetic subtypes. 21152005 2010
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE This series of DS leukemias-the largest to date-reveals that DS-ALL is a heterogeneous disorder that comprises both t(12;21) and HeH as well as DS-related abnormalities. 17971484 2008
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. 17418891 2008
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE The modal chromosome numbers, incidence, types, and numbers of additional abnormalities, genomic imbalances, and chromosomal breakpoints in the 245 karyotypically informative cases, as well as in 152 previously reported cytogenetically characterized t(12;21)-positive ALLs in the same age group, were ascertained. 17285576 2007
Childhood Acute Lymphoblastic Leukemia
0.100 Biomarker disease BEFREE Our data support the involvement of a new locus telomeric to TEL in the pathogenesis of t(12;17)-positive ALL. 16490598 2006