Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Levels of breakpoint t(12;16) and TERT C228T ctDNA correlated with the clinical course and tumor burden in patients with myxoid liposarcomas (n = 4). ctDNA could detect minimal residual disease and tumor recurrence.
|
30779112 |
2019 |
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we report for the first time a novel secondary clonal translocation, t(2;4) (q23;p14) in addition to t(12;16)(q13; p11.2) in a 30-year-old woman with myxoid liposarcoma on the left posterior thigh region without any prior chemoradiation therapy.
|
23958553 |
2015 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid and round cell liposarcomas are characterized by t(12;16)(q13; p11) or t(12;22)(q13;q12) translocations.
|
18517278 |
2008 |
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characteristic sequence motifs located at the genomic breakpoints of the translocation t(12;16) and t(12;22) in myxoid liposarcoma.
|
18752119 |
2008 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As a result of t(12;16) translocations, CHOP is rearranged and fused to TLS in 16p11 in about 90% of myxoid liposarcomas/round cell liposarcomas (MLS/RCLS).
|
11802205 |
2002 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS).
|
11751490 |
2001 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid liposarcoma (LS), the most common subtype of LS, is known to be characterized by the specific t(12;16) resulting in a TLS-CHOP fusion in almost all cases.
|
11229517 |
2000 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid liposarcomas (LPS) are characterized by the t(12; 16)(q13; p11), which leads to the formation of a FUS-CHOP fusion transcript.
|
10809905 |
2000 |
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The same specific translocation t(12;16) and the fusion transcript type II in both components confirmed the close relationship between myxoid and round-cell liposarcomas.
|
10667432 |
1999 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Circumstantial evidence suggests that genetic changes may lead to tumor progression within the myxoid liposarcoma tumors (MLTs) carrying non-random chromosomal translocation t(12;16).
|
9862519 |
1999 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid liposarcomas harbor a unique and specific t(12;16)(q13,p11) chromosomal translocation.
|
10347549 |
1999 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have sequenced the breakpoint regions in one acute myeloid leukemia (AML) with t(16;21)(p11;q22) resulting in the formation of a FUS/ERG hybrid gene and in four myxoid liposarcomas (MLS), three of which had the translocation t(12;16) (q13;p11) and a FUS/CHOP fusion gene and one with t(12;22;20)(q13;q12;q11) and an EWS/CHOP hybrid gene.
|
9315104 |
1997 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Other cytogenetic findings of translocation t(12;16) indicate that round cell liposarcomas share chromosomal changes with myxoid liposarcomas, and further suggest that both tumor subtypes of liposarcoma may possess common precursor cells.
|
9103213 |
1997 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features.
|
9306965 |
1997 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All nine myxoid liposarcomas were shown to be diploid by DNA flow cytometry and exhibited the translocation t(12; 16), as shown by FISH.
|
9010102 |
1997 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A complex translocation involving chromosome 12, 16, and 19 was found, instead of the t(12;16), specific for myxoid liposarcoma.
|
8976371 |
1996 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FUS (TLS) was first identified as the 5'-part of a fusion gene with CHOP (GADD153, DDIT3) in myxoid liposarcomas with t(12; 16)(q13; p11).
|
8921363 |
1996 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have revealed new tumor-specific translocations (eg, cemento-ossifying fibroma and myxoid chondrosarcoma) and the association of established translocations, eg, t(11;22) and t(12;16), in rare histologic subtypes such as biphenotypic sarcomas with myogenic and with neural differentiation and round cell liposarcoma, respectively.
|
8869802 |
1996 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
|
7566973 |
1995 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, six of the translocations, namely the t(11;22), t(21;22), and t(7;22) of Ewing's sarcoma, the t(12;22) of clear cell sarcoma, the t(12;16) of myxoid liposarcoma, and the t(11;22) of desmoplastic small round cell tumor, achieve this following a peculiar pattern, consisting in the fusion of a gene with an RNA-binding domain (EWS or TLS) with a transcription factor gene (FLI1, ERG, ETV1, ATF-1, CHOP, or WT1).
|
7493135 |
1995 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid liposarcomas have a unique and specific t(12;16)q13;p11) chromosomal translocation.
|
7485386 |
1995 |
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, rearrangements of the CHOP gene appear to be specific for myxoid liposarcoma with t(12;16) and are not associated with lipoblastic differentiation.
|
8143276 |
1994 |
Liposarcoma, Myxoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although only a few lipoblastomas have been investigated cytogenetically, it is increasingly clear that these adipose tissue tumor generally show rearrangements of 8q11-q13 region but lack the t(12;16) that allows these tumors to be distinguished from myxoid liposarcomas.
|
7828158 |
1994 |