CD6, CD6 molecule, 923

N. diseases: 216; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Levels of breakpoint t(12;16) and TERT C228T ctDNA correlated with the clinical course and tumor burden in patients with myxoid liposarcomas (n = 4). ctDNA could detect minimal residual disease and tumor recurrence. 30779112 2019
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 Biomarker disease BEFREE Herein, we report for the first time a novel secondary clonal translocation, t(2;4) (q23;p14) in addition to t(12;16)(q13; p11.2) in a 30-year-old woman with myxoid liposarcoma on the left posterior thigh region without any prior chemoradiation therapy. 23958553 2015
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Myxoid and round cell liposarcomas are characterized by t(12;16)(q13; p11) or t(12;22)(q13;q12) translocations. 18517278 2008
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 Biomarker disease BEFREE Characteristic sequence motifs located at the genomic breakpoints of the translocation t(12;16) and t(12;22) in myxoid liposarcoma. 18752119 2008
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE As a result of t(12;16) translocations, CHOP is rearranged and fused to TLS in 16p11 in about 90% of myxoid liposarcomas/round cell liposarcomas (MLS/RCLS). 11802205 2002
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS). 11751490 2001
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Myxoid liposarcoma (LS), the most common subtype of LS, is known to be characterized by the specific t(12;16) resulting in a TLS-CHOP fusion in almost all cases. 11229517 2000
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Myxoid liposarcomas (LPS) are characterized by the t(12; 16)(q13; p11), which leads to the formation of a FUS-CHOP fusion transcript. 10809905 2000
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 Biomarker disease BEFREE The same specific translocation t(12;16) and the fusion transcript type II in both components confirmed the close relationship between myxoid and round-cell liposarcomas. 10667432 1999
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Circumstantial evidence suggests that genetic changes may lead to tumor progression within the myxoid liposarcoma tumors (MLTs) carrying non-random chromosomal translocation t(12;16). 9862519 1999
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Myxoid liposarcomas harbor a unique and specific t(12;16)(q13,p11) chromosomal translocation. 10347549 1999
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE We have sequenced the breakpoint regions in one acute myeloid leukemia (AML) with t(16;21)(p11;q22) resulting in the formation of a FUS/ERG hybrid gene and in four myxoid liposarcomas (MLS), three of which had the translocation t(12;16) (q13;p11) and a FUS/CHOP fusion gene and one with t(12;22;20)(q13;q12;q11) and an EWS/CHOP hybrid gene. 9315104 1997
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Other cytogenetic findings of translocation t(12;16) indicate that round cell liposarcomas share chromosomal changes with myxoid liposarcomas, and further suggest that both tumor subtypes of liposarcoma may possess common precursor cells. 9103213 1997
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features. 9306965 1997
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE All nine myxoid liposarcomas were shown to be diploid by DNA flow cytometry and exhibited the translocation t(12; 16), as shown by FISH. 9010102 1997
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE A complex translocation involving chromosome 12, 16, and 19 was found, instead of the t(12;16), specific for myxoid liposarcoma. 8976371 1996
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE FUS (TLS) was first identified as the 5'-part of a fusion gene with CHOP (GADD153, DDIT3) in myxoid liposarcomas with t(12; 16)(q13; p11). 8921363 1996
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Recent studies have revealed new tumor-specific translocations (eg, cemento-ossifying fibroma and myxoid chondrosarcoma) and the association of established translocations, eg, t(11;22) and t(12;16), in rare histologic subtypes such as biphenotypic sarcomas with myogenic and with neural differentiation and round cell liposarcoma, respectively. 8869802 1996
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). 7566973 1995
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Furthermore, six of the translocations, namely the t(11;22), t(21;22), and t(7;22) of Ewing's sarcoma, the t(12;22) of clear cell sarcoma, the t(12;16) of myxoid liposarcoma, and the t(11;22) of desmoplastic small round cell tumor, achieve this following a peculiar pattern, consisting in the fusion of a gene with an RNA-binding domain (EWS or TLS) with a transcription factor gene (FLI1, ERG, ETV1, ATF-1, CHOP, or WT1). 7493135 1995
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Myxoid liposarcomas have a unique and specific t(12;16)q13;p11) chromosomal translocation. 7485386 1995
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 GeneticVariation disease BEFREE Thus, rearrangements of the CHOP gene appear to be specific for myxoid liposarcoma with t(12;16) and are not associated with lipoblastic differentiation. 8143276 1994
CUI: C0206634
Disease: Liposarcoma, Myxoid
Liposarcoma, Myxoid
0.100 Biomarker disease BEFREE Although only a few lipoblastomas have been investigated cytogenetically, it is increasingly clear that these adipose tissue tumor generally show rearrangements of 8q11-q13 region but lack the t(12;16) that allows these tumors to be distinguished from myxoid liposarcomas. 7828158 1994