|
Multiple Sclerosis
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
Several other independent CD6 gene polymorphisms have been associated with disease susceptibility or with clinical features such as worse attack recovery in MS.
|
26844569 |
2016 |
|
Multiple Sclerosis
|
0.420 |
Biomarker
|
disease |
CTD_human |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Multiple Sclerosis
|
0.420 |
GeneticVariation
|
disease |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
Multiple Sclerosis
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
Our recent meta-analysis of genome-wide association studies of multiple sclerosis (MS) identified a new susceptibility locus tagged by a single nucleotide polymorphism, rs17824933 (p = 3.8 × 10(-9)), that is found in a block of linkage disequilibrium containing the CD6 gene.
|
21849685 |
2011 |
|
Multiple Sclerosis
|
0.420 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
Multiple Sclerosis
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
Multiple Sclerosis
|
0.420 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
Multiple Sclerosis, Acute Fulminating
|
0.300 |
Biomarker
|
disease |
CTD_human |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Multiple Sclerosis, Acute Fulminating
|
0.300 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
Ankylosing spondylitis
|
0.130 |
Biomarker
|
disease |
BEFREE |
Two Medtronic Stealth Station S7™ systems with O-arm image capture were used to guide fixation of C6 and T12, unstable, AO A4, three-column fractures, in a patient with ankylosing spondylitis.
|
28741148 |
2018 |
|
Ankylosing spondylitis
|
0.130 |
Biomarker
|
disease |
BEFREE |
The Safe Correction Angle of Osteotomy at T12 and L1 for Ankylosing Spondylitis Kyphosis: Patients With 2-level Osteotomy.
|
28234777 |
2017 |
|
Ankylosing spondylitis
|
0.130 |
Biomarker
|
disease |
BEFREE |
The combination of T12 paravertebral block, lumbar plexus and sacral plexus block, which may block all nerves innervating the articular capsule, surrounding muscles and the skin involved in total hip arthroplasty, might be a promising alternative for total hip arthroplasty in ankylosing spondylitis.
|
28651520 |
2017 |
|
Ankylosing spondylitis
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.110 |
Biomarker
|
disease |
BEFREE |
The Psoriasis Area Severity Index (PASI) was determined at baseline (T0), at time points T2 (14 days), T4 (4 weeks), T8 (8 weeks), T12 (12 weeks) and 4 weeks after the end of the wash-out period (F1).
|
29048238 |
2017 |
|
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
0.110 |
Biomarker
|
disease |
BEFREE |
Retrospective data analysis at 12 months before (T-12), 6 months before (T-6), at baseline (T+0), 6 months after (T+6) and 12 months after (T+12) rhGH treatment in seven patients with CD (five males).
|
18341091 |
2007 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, this study identifies SPIB as an important target of ETV6-RUNX1 in regulation of B-cell gene expression in t(12;21) leukemia.
|
30986496 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Majority of the patients had<br /> pre-B-cell ALL (88.7%), WBC count <50, 000/μL at diagnosis (76.1%, median = 13.5/μL with a range of 0.51-553.0/<br /> μL) with involvement of central nervous system (CNS) disease in 8.5%patients.Different common chromosomal<br /> anomalies or abnormalities, including t(12, 21) translocation, MLL genre arrangements, trisomy (4, 10, 17)and others,<br /> were detected.
|
31759364 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Levels of breakpoint t(12;16) and TERT C228T ctDNA correlated with the clinical course and tumor burden in patients with myxoid liposarcomas (n = 4). ctDNA could detect minimal residual disease and tumor recurrence.
|
30779112 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A T11 and T12 laminotomy was performed and total removal of the tumour was achieved.
|
29199465 |
2019 |
|
Liposarcoma, Myxoid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Levels of breakpoint t(12;16) and TERT C228T ctDNA correlated with the clinical course and tumor burden in patients with myxoid liposarcomas (n = 4). ctDNA could detect minimal residual disease and tumor recurrence.
|
30779112 |
2019 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, this study identifies SPIB as an important target of ETV6-RUNX1 in regulation of B-cell gene expression in t(12;21) leukemia.
|
30986496 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Notably, the t(12;21) translocation leading to an ETV6-AML1 fusion gene is the most common genetic alteration found in childhood acute lymphoblastic leukemia.
|
30341373 |
2018 |