Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Correlation of Adiponectin With Testosterone in Patients With and Without Type 2 Diabetes and Erectile Dysfunction. 30339037 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Odds ratio showed that lower levels of adiponectin and higher levels of resistin, but not of other cytokines, increased the risk of developing type 2 diabetes mellitus. 31811995 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE In this 10-year prospective study, NGT with higher serum RBP4 and PAI-1, and with lower adiponectin were associated with new-onset prediabetes and type 2 diabetes. 31690939 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Plasma levels of Ad are reduced in obesity, which contributes to type 2 diabetes. 31629112 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE This suggests that treatment of adiponectin effectively improves testicular functions by increasing expression of insulin receptor-mediated increased transport of energy substrate (glucose and lactate) and a marked reduction in oxidative stress are the possible mechanism by which adiponectin effectively improves testicular function in T2D mice. 31676315 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE The adiponectin receptor agonist AdipoRon normalizes glucose metabolism and prevents obesity but not growth retardation induced by glucocorticoids in young mice. 31778708 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Several studies have found that cord blood adiponectin levels are related with postnatal growth trajectories, and it has been suggested that low adiponectin levels in women with pregestational obesity enhance placental insulin sensitivity and activation of placental amino acid transport systems, supporting fetal overgrowth. 31654701 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 GeneticVariation disease BEFREE ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance. 31659105 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Low maternal adiponectin levels in obese mice in late pregnancy are mechanistically linked to in utero programming of cardiac dysfunction in their offspring. 31076636 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Low levels of total and HMW adiponectin may predict the development of NAFL independent of pathophysiological factors including obesity and insulin resistance. 31765666 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 GeneticVariation disease BEFREE A doubling of adiponectin levels was associated with a 30% increased risk of overweight/obesity in boys (RR = 1.30; 95% CI: 1.02, 1.64). 31845502 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Considering that most scientific knowledge on adiponectin dysregulation in obesity is from the study of adipose tissue, the present review summarizes and discusses the literature available to date regarding the effects of obesity on skeletal muscle adiponectin induction, along with the potential effects of different exercise prescriptions on this response in an obesity context. 31706980 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE After pregnancy, adiponectin increased in both groups, but more markedly in OB where it reached trimester 1 levels. 31551485 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Adiponectin, a cytokine released by adipose tissue is associated with these disorders and obesity via inflammatory processes. 31539673 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE We analyzed associations of these polymorphisms with anthropometric parameters, lipid profile, as well as adiponectin, leptin and soluble leptin receptor (sOB-R) levels in prepubertal healthy children, to search for their possible role in the risk of obesity and obesity-related disorders. 31204527 2020
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes
0.600 Biomarker phenotype BEFREE This review focuses on the pathophysiology of insulin and adenosine receptors and l-arginine and adenosine membranes transporters giving an overview of the key adipokines leptin and adiponectin in the foetoplacental vasculature in GDM. 30660686 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE This study aimed to investigate gene-environment interactions among moderate/severe periodontitis, polymorphisms of adiponectin (ADIPOQ)-rs1501299, and leptin receptor (LEPR)-rs1137100 on T2DM risk in Chinese subjects. 31128439 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Scoring of peripheral vascular calcification and peripheral arterial occlusive disease, using CT-scan and color-duplex ultrasonography respectively, were conducted and explored in relation to serum adiponectin level in a cross sectional study of 197 patients with type 2 diabetes. 31168327 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Further research is required to elucidate the role of adiponectin in the development and/or progression of microvascular disease in T2DM patients. 29308741 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The biomarker score that comprised of four biomarkers (TG-to-HDL ratio, ALT, ferritin, and adiponectin) was positively associated with T2DM risk (<i>P</i> trend <0.001). 31769241 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The results of the meta-analysis did not show significant differences (<i>p</i> > 0.05) between low GI and higher GI diets with respect to adiponectin and C-reactive proteins in patients with type 2 diabetes, but a significant difference (<i>p</i> < 0.001) was observed between the two groups in relation to interleukin-6. 31336986 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Association between the -11377 C/G and -11391 G/A polymorphisms of adiponectin gene and adiponectin levels with susceptibility to type 1 and type 2 diabetes mellitus in population from the west of Iran, correlation with lipid profile. 30203461 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE There was a positive association between blood adiponectin and ALMBMI in postmenopausal women without T2DM, but no association in those with T2DM. 31688578 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Polymorphisms in the <i>ADIPOQ</i> gene are known to influence an individual's predisposition to metabolic syndrome and type 2 diabetes. 30863757 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE There was a positive association between blood adiponectin and ALMBMI in postmenopausal women without T2DM, but no association in those with T2DM. 31461078 2019